Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-03-13
1996-09-03
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424450, 424495, 424499, A61K 914
Patent
active
055521606
ABSTRACT:
Dispersible particles consisting essentially of a crystalline NSAID having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm. Pharmaceutical compositions containing the particles exhibit reduced gastric irritation following oral administration and/or hastened onset of action.
REFERENCES:
patent: 2996433 (1961-08-01), Hoppe et al.
patent: 3192118 (1965-06-01), Battista et al.
patent: 4255581 (1980-09-01), Kreuter et al.
patent: 4269821 (1981-05-01), Kreuter et al.
patent: 4826689 (1989-05-01), Violante et al.
patent: 4918103 (1990-04-01), Park et al.
patent: 4944949 (1990-07-01), Story et al.
patent: 5018370 (1991-05-01), Jay et al.
patent: 5091188 (1992-02-01), Haynes
patent: 5110493 (1992-05-01), Chern-Chyi et al.
patent: 5112868 (1992-05-01), Cetenko et al.
patent: 5145684 (1992-09-01), Liversidge et al.
Cioli et al, Tox. and Appl. Pharm., 50, 283-289 (1979) The Role of Direct Tissue Contact in the Production of Gastrointestinal Ulcers by Anti-Inflammatory Drugs in Rats.
Price et al, Drugs, 40, (Suppl. 5):1-11 (1990) Mechanisms of NSAID-Induced Gastroenteropathy.
Aabakken et al, 65-73, Comparison of the Gastrointestinal Side Effects of Naproxen Formulated as Plain Tablets, Enteric-Coated Tablets, or Enteric-Coated Granules in Capsules.
Gursoy et al "Evaluation of Indomethacin Nanocapsules for their Physical Stability and Inhibitory Activaty on Inflammation and Platelet Aggregation" Chemical Abstracts, vol. 111, No. 8, 1989 pp. 101-108.
Conzentino, Jr. Philip
Cundy Kenneth C.
Liversidge Gary G.
Sarpotdar Pramod P.
Benston, Jr. William E.
NanoSystems L.L.C.
Page Thurman K.
LandOfFree
Surface modified NSAID nanoparticles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Surface modified NSAID nanoparticles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Surface modified NSAID nanoparticles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1948458