Surface modified liposomes

Details Surface modified liposomes Surface modified liposomes

1991-07-22

1993-09-28

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435419, 435975, 435970, 436528, 436532, 436829, 436807, 436808, 422 56, 422 58, 422 61, C12Q 128, G01N 33544, G01N 33547

Patent

active

052485900

ABSTRACT:
A liposome reagent encapsulating a molecule to be targeted to a body site or used as an assay reporter has a ligand and a sulfonate-containing group on the liposome surface. Preferred ligands are antibodies or antibody fragments and preferred encapsulants are enzymes or dyes. In the most preferred reagents, the antibody and sulfonate-containing group are covalently bonded to the liposome surface through a connecting group which includes a succinimidyl group resulting from addition of the ligand or sulfonate-containing group to a maleimidyl group. The invention includes a kit of materials for performing an assay using the reagent of the invention as the tracer.

REFERENCES:
patent: 4429008 (1984-01-01), Martin et al.
patent: 4743560 (1988-05-01), Campbell et al.
patent: 4891324 (1990-01-01), Pease et al.
patent: 4948590 (1990-08-01), Hawrot et al.
Bredehorst et al., Biochemistry, 25, 5693 (1986).
Martin et al., Macromolecules as Drugs and as Carriers for Biologically Active Molecules, New York Academy of Sciences, 446, 443, (1985).

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