Surface-modified base matrices

Details Surface-modified base matrices Surface-modified base matrices

2008-09-09

2008-09-09

Zemel, Irina S (Department: 1796)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Cellular products or processes of preparing a cellular...

C521S143000, C521S189000, C523S446000, C523S447000, C525S054300, C526S238220, C526S283000, C502S401000, C502S402000

Reexamination Certificate

active

10517293

ABSTRACT:
The present invention is a surface-modified base matrix comprised of a porous polymeric base matrix onto which branched hydrophilic polyhydroxy-functional polymers have been covalently attached, wherein the polyhydroxy-functional polymers are hyperbranched polymers presenting a degree of branching (DB) of at least about 0.2 and each polymer is tethered to the base matrix at two or more points. The present matrix can for example be a cross-linked carbohydrate material, such as agarose, and the hyperbranched hydrophilic polymer can e.g. be a copolymer of epichiorohydrin and a sugar. The invention also relates to a method of surface-modification of a porous base matrix by activating functional hydroxy groups thereon and contacting the activated matrix with a hydrophilic hyperbranched hydroxy-functional polymer.

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Ling, F., et al., “Effect of Multivalency on the Performance of Enantioselective Separation Media for Chiral HPLC Prepared by Linking Multiple Selectors to a Porous Polymer Support via Aliphatic Dendrons”,J. Org. Chem., vol. 67, 2002, pp. 1993-2002.

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