Surface immobilization of biopolymers

Details Surface immobilization of biopolymers Surface immobilization of biopolymers

1997-12-10

1999-08-24

Houtteman, Scott W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 241, C12Q 168

Patent

active

059423978

ABSTRACT:
In one embodiment, the present invention provides a biopolymer-containing monolayer comprising: thiol-derivatized biopolymers and organic thiols bound to a metal substrate. In another embodiment, the present invention provides a method for forming this biopolymer-containing monolayer. Preferably, the biopolymers are single-stranded DNA probes.

REFERENCES:
patent: 5302509 (1994-04-01), Cheeseman
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5514501 (1996-05-01), Tarlov
patent: 5622826 (1997-04-01), Varma
Leavitt et al., "Angle-Dependent X-ray Photoelectron Spectroscopy and Atomic Force Microscopy of Sulfur-Modified DNA on Au(111)" in J. Phys. Chem., (1994), 98, 8742-8746.
Lee et al., "Direct Measurement of the Forces Between Complementary Strands of DNA" in Science, (1994), 266, 771-773.
Okahata et al., "Hybridization of Nucleic Acids Immobilized on a Quartz Crystal Microbalance" in J. Amer. Chem. Soc., (1992), 114, 8299-8300.

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