Surface expression libraries of heteromeric receptors

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 691, 4351723, 4352523, 4353201, 536 234, C12N 1563, C12N 1513

Patent

active

058719741

ABSTRACT:
A composition of matter comprising a plurality of procaryotic cells containing diverse combinations of first and second DNA sequences encoding first and second polypeptides which form a heteromeric receptor exhibiting binding activity toward a preselected molecule, those heteromeric receptors being expressed on the surface of filamentous bacteriophage.

REFERENCES:
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5427908 (1995-06-01), Dower et al.
patent: 5432018 (1995-07-01), Dower et al.
Barbas, Carlos F. III, et al., "Assembly of Combinatorial Antibody Libraries on Phage Surfaces: The Gene III Site". Proc. Natl. Acad. Sci. USA. 88:7978-7982 (1991).
Clackson, Tim, et al., "Making Antibody Fragments Using Phage Display Libraries". Nature. 352:624-628 (1991).
Hoogenboom, Hennie R. et al., "Multi-Subunit Proteins on the Surface of Filamentous Phage: Methodologies for Displaying Antibody (Fab) Heavy and Light Chains". Nucleic Acids Res. 19:4133-4137 (1991).
Pluckthun, A. "Antibodies from Escherichia coli". Nature. 347:497-498 (1990).
Caton, Andrew J. and Koprowski, Hilary, "Influenza Virus Hemagglutinin-Specific Antibodies Isolated from a Combinational Expression Library are Closely Related to the Immune Response of the Donor". Proc. Natl. Acad. Sci. USA. 87:6450-6454 (1990).
Hellstrom, K.E. et al., "Epitope Mapping and Use of Anti-Idiotypic Antibodies to the L6 Monoclonal Anticarcinoma Antibody". Cancer Res. 50:2449-2454 (1990).
Parmley, Stephen F. and Smith, George P. "Filamentous Fusion Phage Cloning Vectors for the Study of Epitopes and Design of Vaccines". Adv. Exp. Med. Biol. 251:215-218 (1989).
Ward, E. Sally, et al., "Binding Activities of a Repertoire of Single Immunoglobulin Variable Domains Secreted from Escherichia coli". Nature. 341:544-546 (1989).
Reidhaar-Olson, John F. et al., "Combinatorial Cassette Mutagenesis as a Probe of the Informational Content of Protein Sequences". Science. 241:53-57 (1988).
Skerra, Arne and Pluckthun, Andreas, "Assembly of a Functional Immunoglobulin F.sub.v Fragment in Escherichia coli". Science. 240:1038-1041 (1988).
Roberts, S., et al., "Generation of an Antibody with Enhanced Affinity and Specificity for its Antigen by Protein Engineering". Nature. 328:731-734 (1987).
Kunkel, Thomas A., et al., "Rapid and Efficient Site-Specific Mutagenesis Without Phenotypic Selection". Methods in Enzymology. 154:367-382 (1987).
Derbyshire, Keith M., et al., "A Simple and Efficient Procedure for Saturation Mutagenesis Using Mixed Oligodeoxynucleotides". Gene. 46:145-152 (1986).
Smith, George, P., "Filamentous Fusion Phage: Novel Expression Vectors That Display Cloned Antigens on the Virion Surface". Science. 228:1315-1317 (1985).
Cabilly, Samuel et al., "Generation of Antibody Activity From immunoglobulin Polypeptide Chains Produced in Escherichia coli". Proc. Natl. Acad. Sci. USA. 81:3273-3277 (1984).
Better, Marc et al., "Escherichia coli Secretion of an Active Chimeric Antibody Fragment". Science. 240:1041-1043 (1988).
Cwirla, Steven E. et al., "Peptides on Phage: A Vast Library of Peptides for Identifying Ligands". Proc. Natl. Acad. Sci. USA. 87:6378-6382 (1990).
Scott, Jamie K. et al., "Searching for Peptide Ligands with an Epitope Library". Science. 249:386-390 (1990).
Devlin, James J. et al., "Random Peptide Libraries: A Source of Specific Protein Binding Molecules". Science. 249:404-406 (1990).
Parmley, Stephan F. and Smith, George P. "Antibody-selectable Filamentous fd Phage Vectors: Affinity Purification of Target Genes". Gene. 73:305-318 (1988).
Marvin, D.A. et al., "Structure and Assembly of Filamentous Bacterial Viruses". Nature. 253:19-23 (1975).
PNAS, 86:5728-5732, Aug. 1989, Sastry et, al. Cloning of the Immunological Repertoire in Escherichia coli For Generation of Monoclonal Catalytic Antibodies . . .
Science 246: 1275-1281, 8 Dec. 1989, Huse et. al. Generation of a Large Combinatorial Library of Immunoglobulin Repertoire in Phage Lamba.
Gene 73: 305-318, 1988, Parmley et al. Antibody-Selectably Filamentous fd Phase Vectors: Affinity Purification of Target Genes.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Surface expression libraries of heteromeric receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Surface expression libraries of heteromeric receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Surface expression libraries of heteromeric receptors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2061407

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.