Surface explosed immunoglobulin D-binding protein from...

Details Surface explosed immunoglobulin D-binding protein from... Surface explosed immunoglobulin D-binding protein from...

2002-07-01

2008-12-30

Graser, Jennifer E. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S185100, C424S190100, C424S192100, C435S004000, C435S007320

Reexamination Certificate

active

07470432

ABSTRACT:
The present invention relates to a surface exposed protein, which can be detected inMoraxella catarrhalis, having an amino acid sequence as described in SEQ ID NO 1, an apparent molecular weight of 200 kDa and a capacity of selectively binding membrane bound or soluble IgD, to an immunogenic or IgD-binding fragment of said surface exposed protein, and to an immunogenic and adhesive fragment of said surface exposed protein. DNA segments, vaccines, plasmids and phages, non human hosts, recombinant DNA molecules and plants, fusion proteins and polypeptides and fusion products are also described. A method of detecting IgD, a method of separating IgD, a method of isolation of a surface exposed protein ofMoraxella catarrhalisand a method for treatment of an autoimmune disease are also disclosed.

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Arne Forsgren et al., “Isolation and Characterization of Novel IgD-Binding Protein fromMoraxella catarrhalis”, The Journal of Immunology, vol. 167, 2001, pp. 2112 to 2120.
Arne Forsgren et al., “Branhamella catarrhalisActivates Human B Lymphocytes Following Interactions with Surface IgD and Class 1 Major Histocompatibility Complex Antigens”, Cellular Immunology, vol. 112, 1988, pp. 78 to 88.
Thomas F. Tedder, “Immunoglobulin D-Binding Bacteria”, Bacterial Immunoglobulin-Binding Proteins, vol. 1, 1990, pp. 235 to 242.

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