Chemistry: analytical and immunological testing – Optical result
Reexamination Certificate
2011-08-02
2011-08-02
Gakh, Yelena G (Department: 1777)
Chemistry: analytical and immunological testing
Optical result
C436S169000, C436S171000, C436S172000, C422S400000, C422S420000
Reexamination Certificate
active
07989213
ABSTRACT:
Disclosed are Surface Enhanced Resonance Raman Spectroscopy (SERRS) probes and their use in detection methods for bioassays. Further disclosed is signal optimization of surface enhanced resonance Raman probes achieved by chemical modification of the probes. Also disclosed are methods for increasing the Raman cross-section by varying the chemical composition of a linker group linking a signal molecule to a nanoparticle surface. The signal molecules, such as dyes, may be modified with a linker group designed to both enhance the SERRS signal and to couple the signal molecule to the nanoparticle surface.
REFERENCES:
patent: 7897408 (2011-03-01), Iwahori
Drake et al. “Design of a Peptide Linker Group to Increase the Surface Enhanced Raman Spectroscopy Signal Intensity of a Rhodamine—Nanoparticle System”, Journal of Analytical Chemistry, 2010, vol. 65, No. 6, pp. 608-613.
Drake Philip Leslie
Huang Hsiang-Yuan
Birch & Stewart Kolasch & Birch, LLP
Gakh Yelena G
Industrial Technology Research Institute
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