Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1998-10-28
2000-11-21
Snay, Jeffrey
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
436164, 356301, G01N 2165
Patent
active
061498688
ABSTRACT:
A substrate for surface enhanced Raman scattering (SERS) is described in which the analyte is deliberately sandwiched between a colloidal metal nanoparticle and the SERS substrate. In a first embodiment, the analyte is a protein, and the sandwich comprises a protein:Au colloid complex adsorbed to an aggregated Ag sol. Another embodiment concerns a protein:Ag complex, adsorbed to an aggregated Ag sol. In another embodiment, a protein:Au colloid complex is covalently or non-covalently attached to a macroscopic SERS-active substrate. In yet another embodiment, the colloidal nanoparticle is stabilized by a polymeric additive. In yet another embodiment, detection is accomplished at extremely low analyte concentrations. In a final embodiment, control of analyte orientation with respect to the SERS substrate is demonstrated.
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"Protein:Colloid Conjugates for Surface Enhanced Raman Scattering: Stability and Control of Protein Orientation", Christine D. Keating, et al, J. Phys. Chem. B, vol 102 No. 47, pp. 9404-9413, 1998.
"Heightened Electromagnetic Fields Between Metal Nanoparticles: Surface Enhanced Raman Scattering from Metal-Cytochrome c-Metal Sandwiches", Christine D. Keating, et al, J. Phys. Chem. B, vol. 102, No. 47, pp. 9414-9425, 1998.
Keating Christine
Natan Michael J.
Snay Jeffrey
The Penn State Research Foundation
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