Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Patent
1995-10-13
1998-09-29
Gorgos, Kathryn L.
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
435 6, 4352879, 4352887, 935 77, 935 78, C12Q 168
Patent
active
058145168
ABSTRACT:
The subject invention disclosed herein is a new gene probe biosensor and methods thereof based on surface enhanced Raman scattering (SERS) label detection. The SER gene probe biosensor comprises a support means, a SER gene probe having at least one oligonucleotide strand labeled with at least one SERS label, and a SERS active substrate disposed on the support means and having at least one of the SER gene probes adsorbed thereon. Biotargets such as bacterial and viral DNA, RNA and PNA are detected using a SER gene probe via hybridization to oligonucleotide strands complementary to the SER gene probe. The support means supporting the SERS active substrate includes a fiberoptic probe, an array of fiberoptic probes for performance of multiple assays and a waveguide microsensor array with charge-coupled devices or photodiode arrays.
REFERENCES:
patent: 4674878 (1987-06-01), Vo-Dinh
patent: 5266498 (1993-11-01), Tarcha et al.
patent: 5306403 (1994-04-01), Vo-Dinh
patent: 5325342 (1994-06-01), Vo-Dinh
patent: 5341215 (1994-08-01), Seher
patent: 5376556 (1994-12-01), Tarcha et al.
patent: 5400136 (1995-03-01), Vo-Dinh
patent: 5445972 (1995-08-01), Tarcha et al.
D. J. Jeanmaire, R. P. Van Duyne, J. Electronal. Chem., 84, No Month available, 1977.
G. Whitesides, P. Laibnis, Langmuir, 6, pp. 87-95, No Month available, 1990.
A. Pal et al, Analytical Chemistry, 67, p. 3154, No Month available, 1995.
Yung-Fong Cheng et al, Applied spectroscopy, 44, pp. 755-765, No Month available, 1990.
Tuan Vo-Dinh et al, Anal. Chemistry, 66, pp. 3379-3383, Oct., 1994.
Gorgos Kathryn L.
Lockheed Martin Energy Systems, Inc.
Stafford Shelley L.
Starsiak Jr. John S.
LandOfFree
Surface enhanced Raman gene probe and methods thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Surface enhanced Raman gene probe and methods thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Surface enhanced Raman gene probe and methods thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-685657