Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1995-06-07
1998-11-17
Chin, Christopher L.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
427 211, 427 213, 427287, 4273831, 427404, 427414, 422 57, 422 8205, 422 8208, 436172, 436518, 436526, 436527, 436531, 436532, 436534, 436805, G01N 33553
Patent
active
058375520
ABSTRACT:
Surfaced-enhanced, analytical procedures wherein a surfaced article includes a substrate surface, metal islands, a spacing/coupling agent layer, and binding partner molecules which bond with work piece molecules to be detected. A population of spaced apart metal islands are formed on the substrate and have at least some interconnections formed between them. A continuous layer coats the islands and all surfaces between the islands. The continuous layer includes a coupling agent which immobilizes first binding partner molecules. The first partner molecules bond to the coupling agent and the second binding partner molecules bind to the first binding partner molecules to allow detection of presence or concentration of the work piece binding partner molecules.
REFERENCES:
patent: 3926564 (1975-12-01), Giaever
patent: 3979184 (1976-09-01), Giaever
patent: 4090849 (1978-05-01), Healy et al.
patent: 4267234 (1981-05-01), Rembaum
patent: 4267235 (1981-05-01), Rembaum et al.
patent: 4369226 (1983-01-01), Rembaum
patent: 4438239 (1984-03-01), Rembaum et al.
patent: 4978503 (1990-12-01), Shanks et al.
patent: 4992385 (1991-02-01), Godfrey
patent: 5266498 (1993-11-01), Tarcha et al.
patent: 5376556 (1994-12-01), Tarcha et al.
patent: 5378508 (1995-01-01), Castro et al.
patent: 5527712 (1996-06-01), Sheehy
D. A. Weitz, et al., Journal of Electron Spectroscopy and Printed Phenomena (Pgs. 363-370), A Comparison of Raman Scattering, Resonance Raman Scattering, and Fluorescence From Molecules Absorbed on Silver Island Films, .COPYRGT.1983 Elsevier Scientific Publishing Company.
Cotton, et al., J. Phys. Chem. 1986, 90 (Pgs. 6071-6073), Distance Dependence of Surface-Enhanced Resonance Raman Enhancement In Langmiur-Blodgett Dye Multilayers, .COPYRGT.1986 American Chemical Society.
Rohr, et al., Analytical Biochemistry 182 (Pgs. 388-398), Immunoassay Employing Surface-Enhanced Raman Spectroscopy, .COPYRGT.1989 Academic Press, Inc.
Freeman, et al., Science--vol. 267, Mar. 17, 1995 (Pgs. 1629-1632) Self-Assembled Metal Colloid Monolayers: An Approach to SERS Substrates.
Grabar, et al., Analytical Chemistry--vol. 67, No. 4, Feb. 15, 1995 (Pgs. 735-743), Preparation and Characterization of Au Colloid Monolayers, .COPYRGT.1995 American Chemical Society.
Chumanov George
Cotton Therese M.
Sheehy Timothy M.
Sokolov Konstantin
Chin Christopher L.
Medifor, Ltd.
Sherman Kenneth L.
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