Surface-enhanced affinity capture for desorption and detection o

Details Surface-enhanced affinity capture for desorption and detection o Surface-enhanced affinity capture for desorption and detection o

1997-01-17

2000-02-22

Alexander, Lyle A.

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

436174, 436178, 435 6, 435 71, 250287, 250288, 536 254, G01N 33537

Patent

active

060279427

ABSTRACT:
This invention relates generally to a mass spectrometer probe and a method of using said probe for desorption and ionization of analytes. The sample probe comprises an affinity reagent on the probe surface, wherein the affinity reagent is capable of selectively binding an analyte. An analyte bound to the affinity reagent can be desorbed by a high energy source and detected in the mass spectrometer. The probe and methods are useful in detection and analysis of macromolecules such as proteins or other biomolecules.

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