Surface-bound, unimolecular, double-stranded DNA

Details Surface-bound, unimolecular, double-stranded DNA Surface-bound, unimolecular, double-stranded DNA

1996-06-13

1998-06-23

Chambers, Jasemine C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 231, C07H 2100, C07H 2102, C07H 2104, C12Q 168

Patent

active

057707227

ABSTRACT:
Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific interactions between the double-stranded oligonucleotides, and peptides, proteins, drugs and RNA. In a related aspect, the present invention provides libraries of conformationally restricted probes on a solid support. The probes are restricted in their movement and flexibility using double-stranded oligonucleotides as scaffolding. The probes are also useful in various screening procedures associated with drug discovery and diagnosis. The present invention further provides methods for the preparation and screening of the above libraries.

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