Surface active material and process for preparing same

Details Surface active material and process for preparing same Surface active material and process for preparing same

1982-03-04

1983-08-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424199, A61K 3512

Patent

active

043978398

ABSTRACT:
A surface active material having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. This material comprises, based on the dry weight of the material, 68.6-90.7% of phospholipid, 0.3-13.0% of neutral fat, 0.0-8.0% of total cholesterol, 1.0-27.7% of free fatty acids, 0.1-2.0% of carbohydrate, and 0.0-3.5% of protein. The material is produced by subjecting mammalian lung tissue to a series of procedures including acetic acid ester treatment, organic solvent mixture treatment, differential centrifugation, density gradient centrifugation and dialysis, and optionally adding a phosphatidylcholine, a neutral fat, and/or a free fatty acid to the resulting product. A pharmaceutical composition comprising the surface active material is usable for the clinical treatment of respiratory distress syndrome.

REFERENCES:
Harwood et al.-Biochem. J., vol. 151, (1975), pp. 707-714.
King et al.-Am. J. Physiol., vol. 223, (Sep. 1972), pp. 707-726.

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