(+) Suprofen esters and amides as opthalmic anti-inflammatory ag

Details (+) Suprofen esters and amides as opthalmic anti-inflammatory ag (+) Suprofen esters and amides as opthalmic anti-inflammatory ag

1990-08-27

1991-05-07

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 72, A61K 3138, C07D33322

Patent

active

050137514

ABSTRACT:
Disclosed are esters and amides of (+) suprofen, substantially free of the corresponding enantiomorp, (-) suprofen, having enhanced delivery characteristics on topical administration to the eye; also disclosed are pharmaceutical compositions comprising such (+) suprofen derivatives and methods of using them when indicated to achieve an anti-inflammatory effect on topical delivery to the eye.

REFERENCES:
patent: 4159986 (1979-07-01), Clemence
patent: 4559343 (1985-12-01), Han et al.
Van Daele, P. G. H. et al., Arzneim-Forsch (Drug-Res.), 25(10):1495 (1975).

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