Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-11-08
2005-11-08
Henley, III, Raymond J. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S184000
Reexamination Certificate
active
06962910
ABSTRACT:
The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.
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Goldman et al. (Editors). Cecil's Textbook of Medicine (Twenty-First Edition).W.B. Saunders Company. 2000. p. 1060-1074.
Brewer Karen
Swavey Shawn
Henley III Raymond J.
Royds Leslie Alexandra
Virginia Tech Intellectual Properties Inc.
Whitham Curtis & Christofferson, PC
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