Suppressor and progenitor cells

Details Suppressor and progenitor cells Suppressor and progenitor cells

1992-11-04

1999-11-16

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

424 931, 424 9321, 424 937, 424 9371, C12N 508

Patent

active

059856564

ABSTRACT:
Natural suppressor (NS) cells secrete a soluble protein suppressor factor (SF) which suppresses the mixed lymphocyte response. NS cells as described herein are null, i.e., have the phenotype IL-2R.sup.+, CD3.sup.-, CD4.sup.-, CD8.sup.-, TCR.alpha..beta..sup.-, Ig.sup.-, MAC-1.sup.-, or are double negative suppressors (DNS); i.e., have the phenotype IL-2R.sup.+, CD3.sup.+, CD4.sup.-, CD8.sup.-, TCR.alpha..beta..sup.+. Both NS and SF are useful in vivo to confer immunotolerance with respect to allogeneic transplants, and to effect immunosuppression. They also enhance engraftment of transplanted cells. A population of cells can be provided using density gradient separation techniques which is enriched in progenitor cells as identified by the presence of CD34 surface markers.

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