Suppression of thromboxane levels by percutaneous administration

Details Suppression of thromboxane levels by percutaneous administration Suppression of thromboxane levels by percutaneous administration

1992-06-16

1993-08-31

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

A61K 3160

Patent

active

052409171

ABSTRACT:
A method is disclosed for inducing thromboxane suppression in a mammalian subject by percutaneously administering a pharmaceutical composition containing aspirin. Articles useful for practicing the therapeutic methods of the invention are also disclosed.

REFERENCES:
J. E. F. Reynolds et al.: Martindale the Extra Pharmacopoeia, 29th Ed., 1989, pp. 3-8, The Pharmaceutical Press, London, GB.
The Journal of Clinical Investigation, vol. 69, No. 6, Jun. 1982, P. Patrigani et al.: Selective Cumulative Inhibition of Platelet Thromboxane Production by Low-dose Aspirin in Healthy Subjects, pp. 1366-1372.
Chest, vol. 95, No. 2, Feb. 1989, J. Hirsh et al.: Aspirin and other platelet active drugs--Relationship among dose, effectiveness, and side effects, pp. 12S-18S.
Japanese Pharmacology & Therapeutics, Yakuri to Chiryo, vol. 16, No. 1, Jan. 1988, S.-I. Naito et al.: Percutaneous absorption of salicyclic acid derivatives, pp. 17-25.
The Journal of Burn Care & Rehabilitation, vol. 6, No. 6, Nov./Dec. 1985, J. P. Heggers et al.: Thromboxane inhibitors for the prevention of progressive dermal ischemia due to the thermal injury, pp. 466-468.

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