Suppression of T-cell proliferation using peptide fragments of m

Details Suppression of T-cell proliferation using peptide fragments of m Suppression of T-cell proliferation using peptide fragments of m

1995-06-06

2000-03-14

Burke, Julie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

514 12, 514 13, 530300, 530324, 530325, 530326, A61K 3900, A61K 3817, C07K 708, C07K 1447

Patent

active

060369574

ABSTRACT:
Peptides are administered to individuals suffering from multiple sclerosis. The peptides contain immunodominant epitopes of myelin basic protein that are recognized by T-cells from relapsing-remitting multiple sclerosis patients, and that are contained in the 84-102 and 143-168 regions of human MBP.

REFERENCES:
patent: 4634590 (1987-01-01), Cohen et al.
Driscoll et al J immunology vol. 117 No. 1 110, Jul. 1976.
Swanborg J Immunology vol. 114 No. 1 Part 1 191, Jan. 1975.
Martenson J Neurochemistry vol. 40 951, 1983.
Richert et al Annals New York Acad Sci vol. 540 345, 1988.
Richert et al Annal Neurology vol. 26(3) 32, Sep. 1989.
Rujinami et al Science vol. 230:1043-45, 1985.
Uyemura et al J Neurobiology vol. 39:895, 1982.
Hruby et al J Neurochem vol. 44:637, 1985.
Jahnke et al Science vol. 229:282, 1985.
Higgins et al J Immunology vol. 140 No. 2 440, Jan. 1988.
Michael, J.G. Immunological Investigations vol. 18 (9&10) 1049, 1989.
Fridkis-Hareli et al., Proc. Natl. Acad. Sci., 91:4872-4876, May 1994.
Rudick, R.A. NEJM, 337: 1604, 1997.
Higgins et al., J. Immunology, 140:440-445, 1988.
Eylar, Adv. Exp. Med. Bio., 98:259-281, 1978.
Sriram et al., Cell. Immunol., 75:378-382, 1983.
Nagler-Anderson et al., PNAS, 83:7443-7446, 1986.
Schoen, J. Immunol., 128:717-719, 1982.
Higgins et al., Annals Neurology, abstract No. P154, 1986.
Whitacre et al., 6th Int'l. Cong. Immunol., abstract No. 3.62.21, 1986.
Zamvil et al., Nature, 324:258-260, 1986.
Fritz et al., J. Immunol., 134:2328-2332, 1985.
Fritz et al., J. Immunol., 130:191-194, 1983.
Pettinelli et al., J. Immunol., 129:1209-1211, 1982.
Whitaker et al., J. Bio. Chem, 250:9106-9111, 1975.
Thompson et al., Clin. Exp. Immunol., 64:581-586, 1985.
Lider et al., J. Immunol., 142:748-752, 1989.
Friedman et al., PNAS, 91:6688-6692, 1994.
Adorini et al., Nature 342:800-2, 1989.
Allegretta, M., et al., Science, 247:718-721, 1990.
Avrilionis, K. and Boggs, J.M., J. Neuroimmunol. 35:201-10, 1991.
Ben-Nun, A., et al., J. Immunol., 129:303-308, 1982.
Blackman et al., Science 248:1335-41, 1990.
Burns, F.R., et al., J. Exp. Med., 169:27-39, 1989.
Buss et al., Cell 47:1071-77, 1988.
Cresswell, Nature 343:593-94, 1990.
DeFreitas et al., Proc. Natl. Acad. Sci. USA 83:2637-41, 1986.
Gaur et al., Science 258:1491-4, 1992.
Germain, Nature 344:19-22, 1990.
Guillet et al., Nature 324:260-62, 1986.
Guillet et al., Science 235:865-70, 1987.
Hodes et al., Science 246:1041-44, 1989.
Howell, M.D., et al., Science, 246:668-670, 1989.
Janeway, Nature 341:482-83, 1989.
Kaye et al., Nature 341:746-49, 1989.
Lider et al., Ann. N. Y. Acad. Sci., pp. 267-273, 1986.
MacDonald, Science 246:982, 1989.
Martin, R., et al., J. Immunol. 145:540-8, 1990.
Martin, R., et al., J. of Exper. Med. 173:19-24, 1991.
Martin, R., et al., J. Immunol. 148:1359-1366, 1992.
Mokhtarian, F., et al., Nature, 309:356-358, 1984.
Nikolic-Zugic et al., Nature 344:65-67, 1990.
Ogasawara et al., Nature 325:450-52, 1987.
Oksenberg et al., Nature 345:344-46, 1990.
Ota, K, et al., Nature, 346:183-7, 1990.
Pette, M., et al., Proc. Natl. Acad. Sci., USA 87:7968-72, 1990.
Schwartz, Ann. Rev. Immunol. 3:237-61, 1985.
Su, X., et al., J. Neuroimmunol. 34:181-190, 1991.
Vandenbark, A.A., et al., Nature, 341:541-433, 1989.
Weiner et at., (Abstr) Neurology (Suppl. 1) 39:172, 1989.
Wucherpfenning, K.W. et al., Science 248:1016-9, 1990.
Zamvil, S. S., et al., Nature, 324:258-260, 1986.
Bitar, dissertation entitled, The Suppressive Effects of Oral Myelin Basic Protein . . . , 1986.
Nagler-Anderson, dissertation entitled, Immunoregulation of an Exp. Model of Autoimmunity, 1986.
Rothbart, 1st Forum in Virology, pp. 518-520, 1986.
Bitar et al., Cell. Immunol., 112:364-370, 1988.
Eylar et al., Neurochem. Research, 4:249-258, 1979.
Kagnoff, Oral Tolerance, pp. 248-269, 1982.
Mowat, Immunol. Today, 8:93-98, 1987.
Weiner et al., Science, 259:1321-1324, 1993.
Campbell et al, Arch. Neurol., 29:10-15, 1973.
Carnegie et al.,Immunol. 19:55-63, 1970.
Fritz et al., J. Immunol., 130:1024-1026, 1983.
Hashim et al., Arch. Biochem. and Biophy., 156:287-297, 1973.

Affiliated with

Also associated with

Rating

Suppression of T-cell proliferation using peptide fragments of m does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Suppression of T-cell proliferation using peptide fragments of m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Suppression of T-cell proliferation using peptide fragments of m will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-166467