Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1994-11-10
2000-12-26
Priebe, Scott D.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
4353201, 435456, 536 231, 536 2372, C21N 1549, C21N 1586, C21N 15867, C07H 2100
Patent
active
061657948
ABSTRACT:
The present invention provides recombinant vectors comprising polynucleotides encoding defective monomers of HIV (e.g., HIV-1 or HIV-2) protease which are used to interfere with viral maturation. The defective monomers result in the formation of inactive protease heterodimers and thus inhibit the polyprotein processing events that are essential for viral maturation and infectivity.
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Babe Lilia M.
Craik Charles S.
Rose Jason R.
Priebe Scott D.
The Regents of the University of California
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