Suppression of post-transplant arteriosclerosis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Reexamination Certificate

active

10493070

ABSTRACT:
A preventive and/or therapeutic agent for post-transplant arteriosclerosis occurring as a rejection response to organ transplantation or for auto- or allo-arteriovenous graft post-transplant intimal thickening, wherein the agent contains, as an active ingredient, a monocyte chemoattractant protein-1 (MCP-1) function inhibitor. Administration of the MCP-1 function inhibitor enables prevention and treatment of post-transplant arteriosclerosis occurring as a rejection response to organ transplantation or for auto- or allo-arteriovenous graft post-transplant intimal thickening.

REFERENCES:
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5705360 (1998-01-01), Rollins et al.
patent: 5-276986 (1993-10-01), None
patent: 2002-284698 (2002-10-01), None
patent: 96/38559 (1996-12-01), None
Juengst, BMJ Jun. 28, 2003;326(7404):1410-1.
Zhang et al., J Biol Chem. Jun. 3, 1994;269(22):15918-24.
Deonarain, Expert Opin. Ther. Pat, 8: 53-69, 1998.
Chen et al, Transplant immunology, 9: 301-314, 2002.
Romano, Drugs, News Perspect, 16(5): 267-276, 2003.
Thomas et al, Immunological Reviews, 196: 161-175, 2003.
Ogata et al, Cardiology, 101: 144-158, 2004.
Akowuah, et al, Ann Thorac Surg, 76: 959-66, 2003.
Teizo Yoshimura, et al., The Journal of Experimental Medicine, vol. 169, pp. 1449-1459 1989.
Kouji Matsushima, et al., The Journal of Experimental Medicine, vol. 169, pp. 1485-1490 1989.
Teizo Yoshimura, et al., FEBS Letters, vol. 244, No. 2, pp. 487-493 1989.
Israel F. Charo, et al., Proc. Natl. Acad. Sci. USA, vol. 91, pp. 2752-2756 1994.
Shinsuke Yamagami, et al., Biochemical and Biophysical Research Communications, vol. 202, No. 2, pp. 1156-1162 Jul. 29, 1994.
Teizo Yoshimura, et al., The Journal of Immunology, vol. 147, No. 7, pp. 2229-2233 Oct. 1, 1991.
Egashira, Kensuke et al., A novel anti-monocyte chemo-attractant protein-1 gene therapy for atherosclerosis, Japanese Circulation Journal, Mar. 1, 2001, vol. 65, Supplement 1-A, p. 254 (OJ453).
Forsythe, J.L., Graft function and other risk factors as predictors of cardiovascular disease outcome., Transplantation, Sep. 27, 2001, vol. 72, Issue 6 Suppl., S16-9 (abstract) MEDLINE [online]: Retrieved from STN, MEDLINE Accession No. 2001538553.
Zhang, Yu Jun et al., Structure/Activity Analysis of Human Monocyte Chemoattractant Protein-1 (MCP-1) by Mutagenesis, The Journal of Biological Chemistry, Jun. 3, 1994, vol. 269, No. 22, pp. 15918 to 15924.
Egashira, Kensuke et al., Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis, The FASEB Journal, Oct. 2000, vol. 14, Issue 13, pp. 1974 to 1978.
Kirchengast, Michael et al., Endothelin-1 and Endothelin Receptor Antagonists in Cardiovascular Remodeling, Proceedings of the Society for Experimental Biology and Medicine, Sep. 1999, vol. 221, No. 4, pp. 312-325.
Mitsuaki Isobe et al., “Ishoku Shinkan Domyaku Koka no Shinten Kijo to Yobo—in situ RT-PCR-ho ni yoru Kaiseki to Secchaku Sogal ni yoru Chiryo Koka”, Ono Medical Research Foundation, The 8thAnnual Report 1996 Nendo, Aug. 31, 1997, pp. 67 to 76.

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