Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1992-07-23
1994-11-22
Kishore, G. S.
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
239338, 514631, 514637, A61L 904, A61K 31125
Patent
active
053667263
ABSTRACT:
A method of preventing clinically manifest Pneumocystis carinii pneumonia in immunocompromised humans is provided wherein an aerosol of pentamidine is administered to the patient in a manner which delivers the aerosol to the patient's alveoli. Also provided is a method of treating Pneumocystis carinii pneumonia in HIV seropositive individuals comprising administering a therapeutically effective amount of pentamidine aerosol to the HIV positive individual through inhalation. In addition, a method is provided of administering pentamidine to a human comprising aerosolizing a pentamidine solution in a nebulizer system having a one-way valve disposed between the nebulizer and the mouthpiece of the nebulizer system.
REFERENCES:
patent: 3236458 (1966-02-01), Ramis
patent: 3992516 (1976-11-01), Lim
patent: 4253468 (1981-03-01), Lehmbeck
patent: 4268460 (1981-05-01), Boiarski
patent: 4325967 (1982-04-01), Caton
patent: 4619942 (1986-10-01), Tidwell
patent: 4649911 (1987-03-01), Knight et al.
patent: 4719221 (1988-01-01), Morrison
patent: 4757049 (1988-07-01), Plotnikoff
patent: 4853416 (1989-08-01), Anaebonam
patent: 4933347 (1990-06-01), Tidwell
patent: 5049388 (1991-09-01), Knight et al.
patent: 5262157 (1993-11-01), Bernard et al.
Montgomery et al. Lancet. 29th Aug. 1987. D 480.
Medical World News. Jun. 8, 1987.
Girard et al. Antimicrobial Agents. 31, p. 978 1987.
Chest 80, p. 834, 1981. Dolovich et al.
Waldman et al. Am. Rev. of Resp. Disease 108, 1973, 1004.
Waldman et al., Pentamidine Isethionate Levels in Lungs, Livers, and Kidneys of Rats After Aerosol or Intramuscular Administration, Amer. Rev. Res. Diseases, vol. 108:1004-1006, (1973).
Dolovich et al., Aerosol Penetration into the Lung, Chest Supplement, 80:834-836 (1981).
Debs et al., Selective Lung Delivery of Pentamidine by Liposomes, Abstract of the 1985 ICAAC, Abstract No. 550, p. 192 (1985).
Bernard et al., Aerosol Administration Improves Delivery of Pentamidine to the Lungs, Abstract of the 1985 ICAAC, Abstract No. 552, p. 193 (1985).
Debs et al., Successful Treatment of Pneumocystis Carinii Pneumonia in Rats with Aerosolized Pentamidine, International Conference on AIDS, Poster 294, Paris, France, (23-25 Jun. 1986).
Brennessel D. J., and Goldstein J. A., Eflornithine Hydrochloride (DFMO) in the Therapy (rx) of Pneumocystis Carinii Pneumonia (PCP) in AIDS, International Conference on AIDS, Poster 295, Paris, France, (23-25 Jun. 1986).
Kaplan et al., Trimethoprim-Sulfamethoxazole (TMP-SMZ) Prphylaxis of Pneumocystis Carinii Pneumonia (PCP) in AIDS, International Conference on AIDS, Poster 299, Paris, France, (23-25 Jun. 1986).
Bernard et al., International Conference on AIDS, Poster 300, Paris, France, (23-25 Jun. 1986).
Wharton et al., Trimethoprim-Sulfamethoxazole or Pentamidine for Pneumocystis Carinii Pneumonia in the Acquired Immunodeficiency Syndrome, Annals of Internal Medicine, 105:37-44 (1986).
Donnelly, et al, Distribution of Pentamidine in Humans, Abstracts of the 1986 ICAAC, Abstract 696, p. 225 (1986).
Debs R., Targeting of Drugs and Immunodulators for the Treatment of AIDS-Related Opportunistic Infections, The University-wide Task Force on AIDS Annual Meeting, Poster Session, San Diego, Calif., (Mar. 19-20, 1987).
Conte et al., Inhaled or Reduced-Dose Intravenous Pentamidine for Pneumocystis Carinii Pneumonia, Annals of Internal Medicine, vol. 107: 495 (Oct. 1987).
Montgomery et al., Concentration of Pentamidine in Bronchoalveolar Lavage Fluid After Aerosol and Intravenous Administration, 4H AIDS/Poster Symposium (MTPI) Monday 2:00-5:00 pm, Carondelet Ballroom (MH), A167.
Debs et al., Selective Enhancement of Pentamidine Uptake in the Lung by Aerosolization and Delivery in Liposomes, Am. Rev. Respir. Dis. 135:731 (Mar. 1987).
Montgomery et al., Aerosolized Pentamidine as Sole Therapy for Pneumocystis Carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome, The Lancet, pp. 480-483 (Aug. 29, 1987).
Debs et al., Successful Treatment with Aerosolized Pentamidine of Pneumocystis Carinii Pneumonia in Rats, Antimicrobial Agents and Chemotherapy, 31:37-41 (Jan. 1987).
James, J. S., A Breakthrough In Treating Pneumocystis?, San Francisco Sentinel, 15(3):1 (Jan. 16, 1987).
James, J. S., Aerosol Pentamidine: New PCP Prophylaxis and Treatment, Aids Treatment News, Issue No. 23, (Jan. 16, 1987).
Girard et al., Pentamidine Aerosol in Prophylaxis and Treatment of Murine Pneumocystis Carinii Pneumonia, Antimicrobial Agents and Chemotherapy, vol. 31, No. 7, pp. 978-981 (1987).
Aerosol Pentamidine Curbs PCP Recurrence, Medical World News, Jun. 8, 1987.
Jesuthasan et al., Aerosolised Pentamidine, The Lancet, p. 971 (Oct. 24, 1987).
Armstrong et al., Aerosol Pentamidine, Ann. Int. Med., 109:852-854 (1988).
Paton, Aerosolised Pentamidine, The Lancet, p. 1146 (Nov. 14, 1987).
Heley, Aerosolized Pentamidine Treatment at Home, The Lancet, p. 1092 (Nov. 7, 1987).
Montgomery et al., Prophylaxis of Pneumocystis Carinii Pneumonia in Patients Infected with the Human Immunodeficiency Virus Type 1, Seminars in Respiratory Infections, vol. 4, No. 4, pp. 311-317 (Dec. 1989).
Physician's Desk Reference, 1248 (1989).
Brain et al., Deposition of Aerosol in the Respiratory Tract, American Review of Respiratory Disease, vol. 120:1325-1373 (1979).
Golden J., Pulmonary Problems of AIDS, p. 423 AIDS, J. Levy, Marcel Dekker (1988).
Am. Int. Med., 103:782(1985).
Conte J. et al., Use of Specific and Sensitive Assay to Determine Pentamidine Pharmacokinetics in Patients with AIDS, 1986 International AIDS Conference, Poster 296 Jun. 1986.
Conte John E.
Debs Robert J.
Golden Jeffrey A.
Montgomery Alan B.
Dolezalova Hana
Kishore G. S.
The Regents of the University of California
LandOfFree
Suppression of Pneumocystis carinii using aerosolized pentamidin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Suppression of Pneumocystis carinii using aerosolized pentamidin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Suppression of Pneumocystis carinii using aerosolized pentamidin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1989782