Suppression of nuclear factor-κB dependent processes...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S023100, C536S024100, C536S024500, C435S320100

Reexamination Certificate

active

10328861

ABSTRACT:
Antisense oligonucleotides which hybridize with nuclear factor-κB(NF-κB) mRNA and methods of using these oligonucleotides.

REFERENCES:
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G. P. Nolan et al., “DNA Binding and IκB Inhibition of the Cloned p65 Subunit of NF-κB, arel-Related Polypeptide,”Cell, vol. 64, 1991, pp. 961-969.
P.A. Baeuerle, “The Inducible Transcription Activator NF-κB: Regulation by Distinct Protein Subunits,”Biochimica et Biophysica Acta, vol. 1072, 1991, pp. 63-80.
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T. A. Libermann et al., “Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor,”Molecular Cellular Biology, vol. 10, 1990, pp. 2327-2334.
F.J.T. Staal et al, “Intracellular Thiols Regulate Activation of Nuclear Factor κB and Transcription of Human Immunodeficiency Virus,”Proc. Natl. Acad. Sci.USA, vol. 87, 1990, pp. 9943-9947.
Kitajima et al, “Human T-cell Leukemia Virus Type I Tax Transformation is Associated with Increased Uptake of Oligodeoxynucleotides in Vitro and in Vivo*,”J. Biol. Chem., vol. 267, 1992, pp. 25881-25888.
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