Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1993-12-23
1997-12-09
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
424 855, 4242781, 530351, 530330, 530326, 530300, 514 2, 514 12, A01N 3718, A61K 3800, A61K 3938, C07K 200
Patent
active
056957610
ABSTRACT:
The present invention relates to compositions and methods for inhibition of the vasoactive and signal transduction agent nitric oxide (NO), and to therapeutic treatment of diseases or disorders that involve inappropriate or detrimental NO activity. The invention particularly relates to modulation of kidney function. In specific embodiments, osteopontin and a 20-amino acid fragment of osteopontin that contains an Arg-Gly-Asp sequence suppress expression of inducible NO synthase mRNA, and osteopontin suppresses the activity of constitutive NO synthase.
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Denhardt David T.
Heck Diane Elaine
Hwang Shiaw-Min
Laskin Debra L.
Laskin Jeffrey D.
Hutzell Paula K.
Minnifield N. M.
Rutgers University
University of Medicine & Dentistry of NJ
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