Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2004-08-05
2008-09-23
Saunders, David A (Department: 1644)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S885000, C424S810000
Reexamination Certificate
active
07427591
ABSTRACT:
Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reducing the competency of class II MHC molecules for binding antigenic peptides, reducing presentation of antigenic peptides by class II MHC molecules, and suppressing immune responses. The methods may be employed in the treatment of autoimmune diseases, allergic responses, and organ or tissue graft rejection. Pharmaceutical and therapeutic compositions which are peptide based inhibitors of cathepsin S are also described.
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Bogyo Matthew S.
Bryant Paula R.
Chapman Harold A.
Ploegh Hidde L.
Riese Richard J.
Brigham and Women's Hospital
Ropes & Gray LLP
Saunders David A
VanderVegt F. Pierre
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