Suppressant of corneal subepithelial clouding

Details Suppressant of corneal subepithelial clouding Suppressant of corneal subepithelial clouding

1995-03-14

1996-12-17

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514912, A61K 3700

Patent

active

055853544

ABSTRACT:
Suppressant of corneal subepithelial clouding, in particular, one that is capable of effective suppression of corneal subepithelial clouding which can potentially develop after superficial keratectomy with an excimer laser. The suppressant contains gamma-interferon or variants thereof as an active ingredient and it is formulated in dosage forms suitable for topical administration. In may be commonly applied as an eye drop or an ophthalmic ointment after formulation with additives such as isotonizers, buffer agents, stabilizers, antiseptics, pH modifiers and ophthalmic ointment bases.

REFERENCES:
Transcriptional Control of Human Diploid Fibroblast Collagen Synthesis By .gamma.-Interferon, Biochemical and Biophysical Research Communication, vol. 123, No. 1, Aug. 30, 1984 pp. 365-372.
Molecular Cloning of Human Immune Interferon cDNA and its Expression in Eukaryotic Cells, Nucleic Acids Research, vol. 10, No. 8, 1982, pp. 2487-2501.
Expression of Human Immune Interferon cDNA in E. coli and Monkey Cells, Nature, Patrick W. Gray et al., vol. 295, Feb. 11, 1982, pp. 503-508.
Selective Inhibition of Human Diploid Fibroblast Collagen Synthesis by Interferons, Rapid Publication, Sergio Jimenez et al., vol. 74, Sep. 1984, pp. 1112-1116.
Gamma-Interferon Inhibits Collagen Synthesis in Vivo in the Mouse, R. D. Granstein et al., J. Clin. Invest., vol. 79, Apr. 1987, pp. 1254-1258.

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