Suppository dosage form

Details Suppository dosage form Suppository dosage form

1985-02-11

1988-03-22

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Lymphokine

424DIG15, 514198, 514199, 514200, 514206, 514786, 514965, 514970, A61K 902, A61K 962, A61K 936

Patent

active

047327537

ABSTRACT:
Suppositories containing as the active substance a therapeutically effective amount of ceftriaxone, a pharmaceutically compatible salt thereof or a hydrate of one of these compounds, a stabilizer consisting of a mono-, di- or triglyceride of a C.sub.12 -C.sub.18 -fatty acid or of a mixture of such glycerides, a potentiator consisting of an aliphatic C.sub.2 -C.sub.18 -fatty acid, a mono-, di- or triglyceride of a C.sub.2 -C.sub.12 -fatty acid, a partial ester or complete ester of propylene glycol, polyethylene glycol or a carbohydrate with a C.sub.2 -C.sub.12 -fatty acid, a pharmaceutically compatible ester or ether thereof or of a mixutre of the said potentiators and, if desired, customary therapeutically inert adjuvants for suppositories, and their manufacture are described. These have valuable antimicrobial properties.

REFERENCES:
patent: 4156719 (1979-05-01), Sezaki et al.
patent: 4327210 (1982-04-01), Montavon et al.
patent: 4338306 (1982-07-01), Kitao et al.
patent: 4347237 (1982-08-01), Evenstad et al.
patent: 4368185 (1983-01-01), Mizuno et al.
patent: 4462984 (1984-07-01), Mizuno et al.
patent: 4485033 (1984-11-01), Kitao et al.
patent: 4525339 (1985-06-01), Behl et al.

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