Suppository base composition

Details Suppository base composition Suppository base composition

1982-09-27

1984-07-31

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424365, A61K 902

Patent

active

044629842

ABSTRACT:
A suppository base composition comprising 5-80% by weight of polyethylene glycol, 5-80% by weight of triglyceride of fatty acid having 6-22 carbon atoms and 5-80% by weight of a specifically limited alkylene oxide derivative has a melting point of 30.degree.-60.degree. C., a compatibility with both of a polar drug component and a non-polar drug component, and can provide suppositories having excellent moldability and storage stability.

REFERENCES:
patent: 2538127 (1951-01-01), Saunders et al.
patent: 2975099 (1961-03-01), Goyan et al.
patent: 3767801 (1973-10-01), Tuma et al.
patent: 4368185 (1983-01-01), Mizuno et al.
Chem. Abstracts 92, #220693t, (1980) of Japan Kokai Tokkyo Koho, 79, 157820.
Lachman et al., The Theory & Practice of Industrial Pharmacy, 2nd Ed., (1976), Lea & Febiger, Phila., Pa., "Suppositories", pp. 245-269, Semi-Solids, pp. 215-244, Emulsions, pp. 184-214.

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