Suppositories containing analgesics, antipyretics or anti-inflam

Details Suppositories containing analgesics, antipyretics or anti-inflam Suppositories containing analgesics, antipyretics or anti-inflam

1985-06-28

1987-10-13

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

514965, 514966, A61U 900

Patent

active

046997768

ABSTRACT:
A rectally administered unit dosage form comprising a therapeutically effective amount of an analgesic , an antipyretic or an anti-inflammatory agent capable of being absorbed into the bloodstream from a rectal compartment and an adjuvant, said adjuvant comprising lecithin present in said dosage form in a sufficient amount to be effective in enhancing and prolonging the absorption rate of said analgesic, antipyretic or anti-inflammatory agent from the rectal compartment into the bloodstream, in conjunction with a nontoxic, pharmaceutically acceptable carrier and the methods of using said unit dosage form.

REFERENCES:
patent: 1970396 (1934-08-01), Scherer
patent: 2288327 (1942-06-01), Scherer
patent: 2318718 (1943-05-01), Scherer
patent: 4406896 (1983-09-01), Higuchi et al.
patent: 4464363 (1984-08-01), Higuchi et al.
patent: 4612310 (1986-09-01), Knecht
Nishihata et al., Chem. Pharm. Bull., 26:3378-3383 (1978).
"Advances in Pharmaceutical Sciences", edited by Bean, Beckett and Corlass, vol. IV, Academic Press (1974).
Ch. 8, "Suppositories", by Joachim Anschel and Herbert A. Lieberman, Lachman and Lieberman, "Theory and Practive of Industrial Pharmacy", Lea and Febiger (1976).
"Rectal Administration of Drugs", Senior.

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