Supports useful in solid phase synthesis of oligonucleotides

Details Supports useful in solid phase synthesis of oligonucleotides Supports useful in solid phase synthesis of oligonucleotides

1986-06-05

1988-10-25

Kight, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 542, 5253266, 536 185, 556419, 556420, 556421, 556422, 564 79, 564 80, 564 82, 564 89, 564 98, 564 99, 252 6256, C12P 1934, C12P 1938

Patent

active

047805048

ABSTRACT:
Novel supports useful in solid phase synthesis of oligonucleotides of the formula ##STR1## wherein .circle. is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x.sub.1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.

REFERENCES:
patent: 4591614 (1986-05-01), Miller et al.
patent: 4638032 (1987-01-01), Benner
patent: 4659774 (1987-04-01), Webb et al.

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