Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1997-02-26
1999-01-12
Naff, David M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
435177, 435178, 435179, 435182, 435397, 436529, 436530, 530813, 530814, A61K 970, C12N 1112, C12N 1110, C12N 500
Patent
active
058583920
ABSTRACT:
A supported polyionic hydrogel is prepared by impregnating a support matel with a solution of anionic polysaccharide and a solution of cationic polysaccharide where the anionic polysaccharide and cationic polysaccharide react with each other to form a polyionic hydrogel impregnated in the support material. The hydrogel may be dried such as by lyophilization. Preferably, the anionic polysaccharide is xanthan, dicarboxystarch or dicarboxycellulose and the cationic polysaccharide is chitosan. Especially preferred is a polyionic hydrogel formed from xanthan and chitosan. A paper material or a textile material can be used as the support material. A dry supported polyionic hydrogel can be formed as a bandage without active material incorporated therein. The supported polyionic hydrogel may be formed containing a biologically active material by having the active material in either polysaccharide solution or in another solution impregnated into the support material. The biologically active materials can be enzymes, antibody-producing cells or water-soluble drugs such as the antimicrobial agent, chlorohexidine.
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Dumitriu Severian
Guttmann Hilda
Kahane Itzhak
Israel Fiber Institute, State of Israel Ministry & Trade
Naff David M.
Yissum Research Development Company of the Hebrew University of
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