Supported drugs with increased dissolution rate, and a process f

Details Supported drugs with increased dissolution rate, and a process f Supported drugs with increased dissolution rate, and a process f

1994-02-28

1995-09-12

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424 91, 424493, 424497, 424500, 424501, A61K 914

Patent

active

054495210

ABSTRACT:
Supported drugs with an increased dissolution rate, prepared by a process comprising mixing the drug with the support material under dry conditions, co-grinding the mixture in a mill with its grinding chamber saturated with the vapour of one or more solvents able to solubilize the drug or to be adsorbed on the surface of the support material, vacuum-drying the product obtained, and sieving. The drugs obtained in this manner have a reduced heat of fusion, a reduced melting point, an increased dissolution rate and an increased solubilization kinetics.

REFERENCES:
patent: 3079303 (1963-02-01), Raff
patent: 3089824 (1963-05-01), Wurster
patent: 3328256 (1967-06-01), Gaunt
patent: 3499784 (1970-03-01), Bentholm et al.
patent: 3966899 (1976-06-01), Nakai
patent: 4107288 (1978-08-01), Oppenheim
patent: 4111371 (1978-09-01), Melliger
patent: 4639370 (1987-01-01), Carli
patent: 4837031 (1989-06-01), Denton

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