Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2003-09-09
2008-11-04
Lilling, Herbert J. (Department: 1657)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S423000, C435S128000, C435S129000, C435S325000, C435S396000, C435S399000, C435S430100, C623S023580, C623S023750, C623S023760
Reexamination Certificate
active
07445793
ABSTRACT:
The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation into affected parts after the culture, and the mechanical strength is provided sustainable for (weighted) compression at the initial stage of transplantation.The present invention relates to a 3-dimensional porous scaffold for tissue regenerationwhich comprises a structure composed of vertically long-shaped pores having a pore diameter of not less than 10 μm to not more than 500 μm and pore length of not less than 20 μm to not more than 1 cm being juxtaposedly arrangedobtained by a production process comprising rapid freeze-drying as a key technology.Further, the invention relates to the above 3-dimensional porous scaffold in which seeding properties of cells are improved by a pore enlargement treatment of one side face by a separation operation, a salt elution operation of a surface part, or a combination of these operations. It becomes possible to produce a 3-dimensional cell combination having excellent degree of tissue formation and medical treatment effect by seeding a cell or precursor cell derived from a tissue in this scaffold, and culturing them in an artificial environment and/or the living body.
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International Search Report from Corresponding International Application No. PCT/JP03/11471, Dated Feb. 3, 2004, 2 pages.
English Translation of International Preliminary Examination Report, From Corresponding International Application No. PCT/JP03/11471, Dated Sep. 17, 2005, 7 pages.
Fukuchi Takeshi
Hattori Koji
Kaneko Tadashi
Nishi Akiko
Niwa Hideo
Brinks Hofer Gilson & Lione
GC Corporation
Kaneka Corporation
Lilling Herbert J.
Natl. Inst. of Adv. Ind. Science & Tech.
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