Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1998-03-25
1999-11-02
Achutamurthy, Ponnathapura
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
544363, 546156, C07C 6976, C07D40100, C07D21516
Patent
active
059774002
ABSTRACT:
A method for the preparation and purification of compounds using a novel support, a tetrabenzo[a,c,g,i]fluorene group (Tbf) comprising reacting a building block (A) containing a Tbf group (Tbf-A), with a second building block (B), to afford an intermediate compound (Tbg-A-B) followed by purifying the intermediate compound by adsorption on a carbon support, removing the intermediate compound from the support with a solvent and repeating the previous reactions using the required number of building blocks to synthesize the compounds followed by removal of the Tbf group to afford the desired compounds.
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Ramage, et al., Design of An Affinity-based N.sup..alpha. -amino Protecting Group For Peptide Synthesis: Tetrabenzo[a,c,g,I]fluorenyl-17-methyl urethanes (Tbfmoc), Tetrahedron Letters, 1992, 33:3, 385-388.
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DeWitt Sheila Helen
MacDonald Alasdair Arthur
Ramage Robert
Achutamurthy Ponnathapura
Tinney Francis J.
Warner-Lambert & Company
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