Chemistry: analytical and immunological testing – Involving producing or treating antigen or hapten – Producing labeled antigens
Reexamination Certificate
2006-09-05
2006-09-05
Le, Long V. (Department: 1641)
Chemistry: analytical and immunological testing
Involving producing or treating antigen or hapten
Producing labeled antigens
C435S002000, C435S003000, C435S007200, C435S029000, C435S035000, C435S007920, C435S374000, C435S403000, C436S056000, C436S057000, C436S063000, C436S164000, C436S517000, C436S524000, C436S528000, C422S071000
Reexamination Certificate
active
07101719
ABSTRACT:
Disclosed is a method for the measurement of a cellular process, or for the measurement of the effect of a test compound on a cellular process, in one or more different populations of cells. The method comprises providing separate samples of one or more different populations of cells adhering to support particles, the support particles comprising a scintillant substance and being adapted for cell growth. In one embodiment, different samples of cells are introduced into separate reaction vessels in a fluid medium, together with a reagent labelled with a radioisotope, in the presence or the absence of the test compound, under conditions so as to cause a portion of said radiolabelled reagent to become associated with the cells. In another embodiment, multiparameter analysis may be performed to determine the effect of a test compound on a cellular process using two or more different cell populations present in the same well. Measurement of the cellular process, or the effect of a test compound on a cellular process may be made by detecting light emission from the scintillant particles caused by radioactive decay of the radioisotope.
REFERENCES:
patent: 5512474 (1996-04-01), Clapper et al.
patent: 5989854 (1999-11-01), Cook
patent: 6524786 (2003-02-01), Jessop
patent: WO 96/19739 (1996-06-01), None
Cook, N.D., Scintillation Proximity Assay: a versatile high-throughput screening technology, Drug Discovery Today, vol. 1 (7): 287-294 (1996)).
Ismail Rahman Aziz
O'Beirne Gerard Bernard
Thomas Nicholas
Gabel Gailene R.
GE Healthcare Limited
Ji Yonggang
Le Long V.
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