Supplemented and unsupplemented tissue sealants, method of their

Details Supplemented and unsupplemented tissue sealants, method of their Supplemented and unsupplemented tissue sealants, method of their

1995-06-07

2000-09-12

Woodward, M Patrick

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

4241981, 424443, 424444, 424484, 424499, 424529, 514 2, 514 54, 514 55, 514 56, 530381, 530382, 530399, A61K 3848, A61K 970, A61L 1516

Patent

active

061174254

ABSTRACT:
This invention provides supplemented tissue sealants, methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one cytotoxin or cell proliferation inhibiting composition. The composition may be further supplemented with, for example, one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, cytokines, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.

REFERENCES:
patent: Re33375 (1990-10-01), Luck et al.
patent: 2533004 (1950-12-01), Ferry et al.
patent: 3089815 (1963-05-01), Lieb et al.
patent: 3523807 (1970-08-01), Gerendas
patent: 3723244 (1973-03-01), Breillatt, Jr.
patent: 4265233 (1981-05-01), Sugitachi et al.
patent: 4298598 (1981-11-01), Schwarz et al.
patent: 4321711 (1982-03-01), Mano
patent: 4359049 (1982-11-01), Redl et al.
patent: 4362567 (1982-12-01), Schwarz et al.
patent: 4373519 (1983-02-01), Errede et al.
patent: 4377572 (1983-03-01), Schwarz et al.
patent: 4393041 (1983-07-01), Brown et al.
patent: 4394370 (1983-07-01), Jefferies
patent: 4414976 (1983-11-01), Schwarz et al.
patent: 4427650 (1984-01-01), Stroetmann
patent: 4427651 (1984-01-01), Stroetmann
patent: 4442655 (1984-04-01), Stroetmann
patent: 4453939 (1984-06-01), Zimmerman et al.
patent: 4472840 (1984-09-01), Jefferies
patent: 4516276 (1985-05-01), Mittelmeier et al.
patent: 4548736 (1985-10-01), Muller et al.
patent: 4600574 (1986-07-01), Lindner
patent: 4617293 (1986-10-01), Wahlig et al.
patent: 4619913 (1986-10-01), Luck
patent: 4619989 (1986-10-01), Urist
patent: 4627879 (1986-12-01), Rose et al.
patent: 4631055 (1986-12-01), Redl et al.
patent: 4642120 (1987-02-01), Nevo et al.
patent: 4708861 (1987-11-01), Popescu
patent: 4714457 (1987-12-01), Alterbaum
patent: 4717717 (1988-01-01), Finkenaur
patent: 4761471 (1988-08-01), Urist
patent: 4789732 (1988-12-01), Urist
patent: 4816339 (1989-03-01), Tu et al.
patent: 4820626 (1989-04-01), Williams et al.
patent: 4837379 (1989-06-01), Weinberg
patent: 4861757 (1989-08-01), Antoniades et al.
patent: 4874746 (1989-10-01), Antoniades et al.
patent: 4909251 (1990-03-01), Seelich
patent: 4928603 (1990-05-01), Rose et al.
patent: 4952403 (1990-08-01), Vallee et al.
patent: 4969880 (1990-11-01), Zamierowski
patent: 4983581 (1991-01-01), Antoniades et al.
patent: 5019559 (1991-05-01), Antoniades et al.
patent: 5023082 (1991-06-01), Friedman et al.
patent: 5030215 (1991-07-01), Morse et al.
patent: 5034375 (1991-07-01), Antoniades et al.
patent: 5035887 (1991-07-01), Antoniades et al.
patent: 5059123 (1991-10-01), Jernberg
patent: 5124155 (1992-06-01), Reich
patent: 5139527 (1992-08-01), Redl et al.
patent: 5171318 (1992-12-01), Gibson et al.
patent: 5171579 (1992-12-01), Ron et al.
patent: 5176916 (1993-01-01), Yamanaka et al.
patent: 5209776 (1993-05-01), Bass
patent: 5219328 (1993-06-01), Morse et al.
patent: 5226877 (1993-07-01), Epstein
patent: 5290552 (1994-03-01), Sierra et al.
patent: 5368858 (1994-11-01), Hunziker
patent: 5395923 (1995-03-01), Bui-Khac et al.
patent: 5464471 (1995-11-01), Whalen et al.
patent: 5552452 (1996-09-01), Khadem et al.
patent: 5716645 (1998-02-01), Tse
Stemberger, A. et al., The Thoracic and Cardiovascular Surgeon, vol. 30(4), pp. 209-214, Aug. 1982.
Kang, S.S. et al., Surgery, vol. 118(12), pp. 280-287, Aug. 1995.
Kabuto, M. et al., Surg. Neurol., vol. 44, pp. 151-157, 1995.
Spinuzza Harris, E. et al., Surgical Forum, vol. 43(0), pp. 515-516, 1992.
Kang, S.S. et al., Owen H. Wangensteen Surgical Forum, vol. 45(0), pp. 355-359, 1994.
Wadstrom, J., Fibrin Sealing Surg. Nonsurg. Fields, vol. 1, pp. 136-143, 1994.
Howell, J.M. et al., Emergency Medicine Clinics of North America, vol. 10(4), pp. 655-663, Nov. 1992.
Lasa, C.I. Jr., et al., Journal of Surgical Research, vol. 54(3), pp. 202-206, Mar. 1993.
Epstein, G.H. et al., "A New Autologous Fibrinogen-Based Adhesive For Otologic Surgery," Ann. Otol. Rhinol. Laryngol. 95:40-45 (1986).
Gersdorff, M.C.H. et al., "A New Procedure For Bone Reconstruction In Oto-Microsurgery: A Mixture Of Bone Dust And Fibrinogen Adhesive," Laryngosc. 95:1278-1280 (1985).
Harting, F. et al., "Glued Fixation of Split-Skin Graft to the Bony Orbit Following Exenteration," Plas. Reconstruc. Surg. 76(4):633-635 (1985).
Ikossi-O'Connor, M.G. et al., "The Role of Fibrin Adhesive in Vascular Surgery," J. Surg. Oncol. 23:151-152 (1983).
Petrelli, N.J. et al., "The Application of Tissue Adhesives in Small Bowel Anastomoses," J. Surg. Oncol. 19:59-61 (1982).
Thompson, D.F. et al., "Fibrin Glue: A Review Of Its Prepartion, Efficacy, And Adverse Effects As A Topical Hemostat," Dr. Intell. Clin. Pharm. 22:946-952 (1988).
Thorson, G.K. et al., "The Role of the Tissue Adhesive Fibrin Seal (FS) in Esophageal Anastomoses," J. Surg. Oncol. 24:221-223 (1983).
Larson, M.J. et al., "Efficacy of a Fibrin Hemostatic Bandage in Controlling Hemorrhage From Experimental Arterial Injuries," Arch. Surg. 130:420-422 (1995).
MacPhee, M., "Fibrin Sealant Based Bandages and Foam: Hemostatic Devices for Treatment of Combat Casualties on the Battlefield," Presented at the Advanced Technology Applications to Combat Casualty Care (ATACCC) conference (May 1995).
MacPhee, M., "Field-Ready Fibrin Sealant Based Hemostatic Devices," Presented at the 29th Penner Blood Conference (May 1995).
Adelmann-Grill et al., "Chemotactic Migration of Normal Dermal Fibroblasts Towards Epidermal Growth Factor and Its Modulation by Platelet-Derived Growth Factor and Transforming Growth Factor-Beta," European J. Cell. Biol. 51:322-326 (Apr., 1990).
Akrami et al., "Replacement of the Thoracic Aorta by Sealed Dacron Prostheses," Thoraxchirurgie 26:144-147 (1978).
Albrektsson et al., "Fibrin Adhesive System (FAS) Influence on Bone Healing Rate," Acta Orthop. Scand. 53:757-763 (1982).
Allen et al., "Influence on Endothelial Cell Seeding on Platelet Deposition and Patency in Small-Diameter Dacron Arterial Grafts," J. Vasc. Surg. 1:224-233 (1984).
Arbes et al., "First Clinical Experience with Heterologous Cancellous Bone Grafting Combined with the Fibrin Adhesive System (F.A.S.)," Arch. Orthop. Traumat. Surg. 98:183-188 (1981).
Baird et al., "Fibroblast Growth Factors," British Medical Bulletin 45(2):438-452 (1989).
Berger et al., "Healing of Arterial Prostheses in Man: Its Incompleteness," Ann. Surg. 175(1):118-127 (1972).
Borst et al., "Fibrin Adhesive: An Important Hemostatic Adjunct in Cardiovascular Operations," J. Thorac. Cardiovasc. Surg. 84:548-553 (1982).
Bosch, V.P., "Autologous Cancellous Bone Grafting in Rabbits Using a Fibrinogen Adhesive System," Wiener klinische Wochenschrift 91(18):628-633 (1979).
Bosch, V.P., "Bone Grafting with Fibrin Glue," Wein Klin. Wochenschr. 93(Suppl. 124):3-26 (1981).
Bosch, V.P., "Experimental Investigations of the Effect of the Fibrin Adhesive on the Kiel Heterologous Bone Graft," Arch. Orthop. Traumat. Surg. 96:177-185 (1980).
Bosch et al., "The Technic of Fibrin Glue in Cancellous Bone Transplants," Arch. Orthop. Unfall-Chir. 90:63-75 (1977).
Burgess et al., "The Heparin-Binding (Fibroblast) Growth Factor Family of Proteins," Annual Rev. Biochem. 58:575-606 (1989).
Byrne et al., "Effect of Fibrin Glues on the Mechanical Properties of Healing Wounds," Br. J. Surg. 78:841-843 (Jul., 1991).
Carter et al., "Clinical Experience with Crude Preparations of Growth Factors in Healing of Chronic Wounds in Human Subjects," in: Growth Factors and Other Aspects of Wound Healing: Biological and Clinical Implications, pp. 303-317 (1988).
Clowes et al., "Graft Endothelialization: The Role of Angiogenic Mechanisms," J. Vascular Surgery 13(5):734-736 (May, 1991).
Clowes et al., "Mechanisms of Arterial Graft Healing," Am. J. Pathol. 123(2):220-230 (1986).
Conant et al., "Treatment of Condylomata Acuminata with Intralesional 5-Fluorouracil Therapeutic Implant (MPI 5003)," Clinical Res. 39(4):818A (Dec.

Affiliated with

Also associated with

Rating

Supplemented and unsupplemented tissue sealants, method of their does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Supplemented and unsupplemented tissue sealants, method of their, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Supplemented and unsupplemented tissue sealants, method of their will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-93121