Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1990-11-26
1992-11-17
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, 536 21, 536 54, 536 551, 536 553, 536122, A61K 31725, C08B 3910
Patent
active
051643782
ABSTRACT:
A process for the depolymerization and supersulfation of heparin and the so obtained supersulfated heparins are disclosed. The process comprises treating heparin with oleum containing from 2 to 6% free sulfuric anhydride at a temperature from -10.degree. to +20.degree. C. The obtained heparins have molecular weights from 2000 to 5000 and a sulfation degree from 3.4 to 4.3. All of them are endowed with a remarkable antithrombotic activity.
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Nagasawa et al; Carbohydrate Research 18:95-102 (1971).
Casati Paolo
Conti Renato
Gorini Maria B.
Maggi Antonio
Carson Nancy S.
Griffin Ronald W.
Iketon Farmaceutici, S.r.l.
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