Supersaturated transdermal drug delivery systems, and methods fo

Details Supersaturated transdermal drug delivery systems, and methods fo Supersaturated transdermal drug delivery systems, and methods fo

1996-09-04

1999-05-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61F 1302

Patent

active

059068302

ABSTRACT:
Methods are provided for manufacturing transdermal drug delivery systems containing supersaturated drug reservoirs, such that higher drug fluxes are obtained. The methods involve heating the drug reservoir components to a predetermined temperature. Generally, this temperature is higher than the depressed melting temperature of the polymer-drug admixture which will serve as the drug reservoir. In an alternative embodiment, wherein heat treatment of the reservoir components results in a system having two liquid phases, the predetermined temperature is calculated so as to be higher than the melting temperature of the pure drug. Drug reservoirs and novel transdermal delivery systems prepared using the disclosed techniques are provided as well.

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Davis et al., "Effect of Supersaturation on Membrane Transport on Membrane Transport: 1. Hydrocortisone Actate," Intl. J. of Pharm. 76:1-8 (1991).
Pellet et al., "Effect of Supersaturation on Membrane Transport: 2. Piroxicam," Intl. J. of Pharm. 111:1-6 (1994).

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