Superparamagnetic contrast media coated with starch and polyalky

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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A61B 5055

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active

061239208

ABSTRACT:
The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.

REFERENCES:
patent: 3935187 (1976-01-01), Speakman
patent: 4101435 (1978-07-01), Hasegawa et al.
patent: 4335094 (1982-06-01), Mosbach
patent: 4357259 (1982-11-01), Senyei et al.
patent: 4452773 (1984-06-01), Molday
patent: 4501726 (1985-02-01), Schroder
patent: 4647447 (1987-03-01), Gries et al.
patent: 4675173 (1987-06-01), Widder
patent: 4731239 (1988-03-01), Gordan
patent: 4735796 (1988-04-01), Gordon
patent: 4770183 (1988-09-01), Groman et al.
patent: 4795698 (1989-01-01), Owen et al.
patent: 4827945 (1989-05-01), Groman et al.
patent: 4849210 (1989-07-01), Widder
patent: 4863715 (1989-09-01), Jacobsen et al.
patent: 4871716 (1989-10-01), Longo et al.
patent: 4904479 (1990-02-01), Illum
patent: 4951675 (1990-08-01), Groman et al.
patent: 5055288 (1991-10-01), Lewis et al.
patent: 5069216 (1991-12-01), Groman et al.
patent: 5102652 (1992-04-01), Groman et al.
patent: 5114703 (1992-05-01), Wolf et al.
patent: 5160725 (1992-11-01), Pilgrimm
patent: 5204445 (1993-04-01), Maruno et al.
patent: 5219554 (1993-06-01), Groman et al.
patent: 5225282 (1993-07-01), Chagnon et al.
patent: 5248492 (1993-09-01), Groman et al.
patent: 5262176 (1993-11-01), Palmacci et al.
patent: 5284646 (1994-02-01), Menz et al.
patent: 5314679 (1994-05-01), Lewis et al.
patent: 5328681 (1994-07-01), Kito et al.
patent: 5342607 (1994-08-01), Josephson
patent: 5349957 (1994-09-01), Yudelson
patent: 5352432 (1994-10-01), Menz et al.
patent: 5358702 (1994-10-01), Unger
patent: 5368840 (1994-11-01), Unger
patent: 5382468 (1995-01-01), Lewis et al.
patent: 5411735 (1995-05-01), Kirpotin et al.
patent: 5424419 (1995-06-01), Hasegawa et al.
patent: 5427767 (1995-06-01), Kresse et al.
patent: 5464696 (1995-11-01), Tournier et al.
patent: 5496536 (1996-03-01), Wolf
patent: 5512332 (1996-04-01), Liberti et al.
Parovuori et al., Starch, 1995 vol. 47, No. 1, pp. 19-23.
Autio et al., Carbohydrate Polymers, vol. 29, No. 2, Feb. 1996, pp. 155-161.
Wang, Chemical Abstracts, vol. 115, No. 10, 1991, abstract No. 093953.
Hasegawa, et al., Chemical Abstracts, 1969, vol. 70, No. 12, abstract No. 050898.
Kresse et al., Magnetopharmaka Deutsche Apotheker Zeitung, vol. 134, No. 33, 1994, pp. 13-14, 17-20, 23-25, (Description by Applicant Only).
Bach-Gansmo T, Fahlvik AK, Ericsson A, Hemmingsson A. Superparamagnetic iron oxide for liver imaging. Comparison among three different preparations. Invest. Radiol. 1994 29(3):339-344.
Chouly C, Pouliquen D, Lucet I, Juene JJ, Jallet P. Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution. J. Microencapsulation 1996 13(3):245-255.
Fahlvik AK, Holtz, E, Klaveness J. Relaxation efficacy of paramagnetic and superparamagnetic microspheres in liver and spleen. Magn. Reson. Imaging 1990 8:363-369.
Fahlvik AK, Holtz E, Leander P, Schroder U, Klaveness J. Magnetic starch microspheres: efficacy and elimination: a new organ-specific contrast agent for magnetic resonence imaging. Invest. Radiol. 1990 25: 113-120.
Cerdan S, Lotscher HR, Kunnecke B, Seeling J. Monoconal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors. Magn. Reson. Med. 1989 12:151-163.
Fahlvik Ak, Naevestad A, Ege T, Froysa A, Sonstevold A, Strande P, Ostensen J. Significance of surface properties in the devlopment of biocompatible iron oxide contrast agents. Proceedings of the 4th Special Top Seminar of the European Magnetic Resonance Forum. Santiago de Compostela, Spain Sep. 28-30, 1994 pp. 105-116.
Fahlvik AK, Artusson P, Edman P. Magnetic starch microspheres: interactions of a microshpere MR contrast medium with macrophages in vitro. Int. J. Pharm. 1990 65(3):249-259.
Fahlvik AK, Holtz E, Schroder U, Klaveness J. Magnetic starch microspheres, biodistribution and biotransformation. A new organ -specific contrast agent for magnetic resonance imaging. Invest. Radiol. 1990 25(7):793-797.
Gunderson HG, Bach-Gansmo T, Holtz E, Fahlvik AK, Aune O, Berg A. Superparamagnetic contrast agents for magnetic resonance imaging. Invest. Radiol. 1990 25(Suppl. 1):S67-S68.
Thomassen T, Nordby Wiggen U, Gundersen HG, Fahlvik AK, Aune O, Klaveness J. Structure activity relationship of magnetic particles as MR contrast agents. Magn. Reson. ImG. 1991 9:255-258.
Colet JM, Muller RN. Effect of opsinins on the uptake of magnetic starch microspheres by rat kupffer cells. MAGMA 1994 2:303-305.
Furusawa K, Nagashima K, Anzai C. Synthetic process to control the total size and component distribution of multilayer magnetic composite particles. Coll. Polym. Sci. 1994 272:1104-1110.
Lee J, Isobe T, Senna M. Preparation of Ultrafine Fe3 O4 particles by precipitation in presence of PVA at high pH. J. Coll. Interf. Sci. 1996 177:490-494.
Mann S, et al. Crystallization at inorganic-organic interfaces: biominerals and biomimetic synthesis. Science 1993 261:1286-1292.
Shinkai M, Honda H, Koobayashi T. Preparation of fine magnetic particles and application for enzyme immobilization. Biocatalysis 1991 5:61-69.
Synthesis of nanoscale iron oxide structures using protein cages and polysaccharide networks. NATO ASI Ser. Ser E 1994 260:49-56.

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