Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases
Patent
1996-06-21
1998-07-14
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Oxidoreductases
4351723, 435189, A61K 3844, C12N 1500, C12N 902
Patent
active
057800243
ABSTRACT:
Disclosed is a 68 kD recombinant hybrid protein comprising an enzymatically active Cu/Zn superoxide dismutase ("SOD-1") moiety and a tetanus toxin fragment C ("TTC") moiety, wherein the TTC moiety selectively delivers the hybrid protein into neurons, and the SOD-1 moiety retains substantial enzymatic activity, following neuronal uptake. Also disclosed are a DNA expression vector encoding the hybrid protein.
REFERENCES:
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Brown Robert H.
Fishman Paul S.
Francis Jonathan W.
Hosler Betsy A.
Stole Einar
The General Hospital Corp.
University of Maryland at Baltimore
Wax Robert A.
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