Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2010-03-24
2011-11-29
Fay, Zohreh (Department: 1627)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S184000, C514S912000
Reexamination Certificate
active
08067405
ABSTRACT:
The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
REFERENCES:
patent: 5075116 (1991-12-01), LaHaye et al.
patent: 5510383 (1996-04-01), Bishop et al.
patent: 5696109 (1997-12-01), Malfroy-Camine et al.
patent: 5994339 (1999-11-01), Crapo et al.
patent: 6046188 (2000-04-01), Malfroy-Camine et al.
patent: 6127356 (2000-10-01), Crapo et al.
patent: 6177419 (2001-01-01), Campbell et al.
patent: 6180620 (2001-01-01), Salvemini
patent: 6214817 (2001-04-01), Riley et al.
patent: 6541490 (2003-04-01), Campbell et al.
patent: 2006/0035880 (2006-02-01), Klimko et al.
patent: 9858636 (1998-12-01), None
patent: 9923097 (1999-05-01), None
patent: 0007584 (2000-02-01), None
patent: 0019993 (2000-04-01), None
patent: 0072893 (2000-12-01), None
patent: 2004052283 (2004-06-01), None
Allikmets R, et al., “Mutation of the Stargardt Disease Gene (ABCR) in Age-Related Macular Degeneration”, Science, 277:1805-1807 (1997). Listed as “Dean” in application.
Baker et. al., “Synthetic Combined Superoxide Dismutase/Catalase Mimetics Are Protective as a Delayed Treatment in a Rat Stroke Model: A Key Role for Reactive Oxygen Species in Ischemic Brain”, J. Pharmacol. Exp. Ther., vol. 284:215-221, 1998.
Bazan; “Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors”; Trends in Neurosciences; vol. 29; No. 5; pp. 263-271; May 2006.
Ben-Shabat et al., “Fluorescent Pigments of the Retinal Pigment Epithelium and Age-Related Macular Degeneration”, Bioorganic & Medicinal Chemistry Letters, 11:1533-1540, 2001. Listed as “Nakanishi” in application.
Brownlee, M., “Biochemistry and Molecular Cell Biology of Diabetic Complications”, Nature, vol. 414:813-820, 2001.
Coppey, et al., “Effect of M40403 Treatment of Diabetic Rats on Endoneurial Blood Flow, Motor Nerve Conduction Velocity and Vascular Function of Epineural Arterioles of the Siatic Nerve,” British Journal of Pharmacology, vol. 134:21-9, 2001 (M40403).
Delcourt, et al., “Associations of Antioxidant Enzymes with Cataract and Age-related Macular Degeneration”, Ophthalmology, Feb. 1999, pp. 215-221, vol. 106, No. 2.
De La Paz, et al., “Red Blood Cell Antioxidant Enzymes in Age-related Macular Degeneration”, British Journal of Ophthalmology, 1996, pp. 445-450, vol. 80.
Doctrow et. al., “Salen-Manganese Complexes as Catalytic Scavengers of Hydrogen Peroxide and Cytoprotective Agents: Structure-Activity Relationship Studies”, J. Med. Chem., 45:4549-4558 (2002).
Gürler, et al., “The Role of Oxidative Stress in Diabetic Retinopathy” Eye, vol. 14:730-735, 2000.
Guzik, et al., “Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus” Circulation, vol. 105:1656-62, 2002.
Kimura K et al., “Genetic Association of Manganese Superoxide Dismutase With Exudative Age-related Macular Degeneration”, American Journal of Ophthalmology, 130(6):769-773 (2000). Listed as “Isashiki” in the application.
Mata NL et al., “Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration”, Proc. Natl. Acad. Sci. USA, 97(13):7154-7159 (2000). Listed as “Travis” in the application.
Melov et. al., “Lipespan Extension and Rescue of Spongiform Encephalopathy in Superoxide Dismutase 2 Nullizygous Mice Treated with Superoxide Dismutase-Catalase Mimetics”, J. Neurosci., vol. 21:8348-8353, 2001.
Parish et al. (Nakanishi), “Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium”, Proc. Natl. Acad. Sci. USA, 95:14609-14613, 1998.
Piganelli, et al., “A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-cell Clone,” Diabetes, vol. 51:347-55, 2002.
Salvemini D, et. al., “A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats”, Science, vol. 286:304-306, 1999.
Salvemini, et al., “M40403 Superoxide Dismutase Mimetic”, Drugs of the Future, 25(10):1027-1033, 2000.
Shamsi and Boulton, “Inhibition of RPE Lysosomal and Antioxidant Activity by the Age Pigment Lipofuscin”, Invest. Ophthalmol. Vis. Sci., vol. 42:3041-3046, 2001.
Shurtz-Swirski et al., “Involvement of Peripheral Polymorphonuclear Leukocytes in Oxidative Stress and Inflammation in Type 2 Diabetic Patients,” Diabetes Care, vol. 24:104-110, 2001.
Wang et. al., “Tempol, a Superoxide Dismutase Mimic, Ameliorates Light-Induced Retinal Degeneration”, Res. Commun. Mol. Pathol. Pharmacol., 89(3):291-305, 1995.
Wassell et al., “The Photoeactivity of the Retinal Age Pigment Lipofusin”, J. Biol. Chem., 274:23828-23832, 1999.
Wihlmark et. al., “Lipofuscin Accumulation in Cultured Retinal Pigment Epithelial Cells Causes Enhanced Sensitivity to Blue Light Irradiation”, Free Radical Biol. Med., 22:1229-1234, 1997.
Winkler, et. al., “Oxidative damage and age-related macular degeneration”, Mol. Vision, vol. 5:32, 1999.
European Search Report from corresponding European Patent application publication No. 0739218 dated Oct. 30, 1996.
Collier, Jr. Robert J.
Hellberg Mark R.
Klimko Peter G.
Derry Jason J.
Fay Zohreh
Novartis AG
LandOfFree
Superoxide dismutase mimics for the treatment of ocular... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Superoxide dismutase mimics for the treatment of ocular..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Superoxide dismutase mimics for the treatment of ocular... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4308518