Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1987-03-31
1993-06-29
Patterson, Jr., Charles L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
424 944, 424DIG6, 435184, A61K 3116, A61K 3750, C12N 902
Patent
active
052235386
ABSTRACT:
The invention relates to a water-soluble complex formed between a chelating agent and manganese and pharmaceutical compositions thereof. The complex is a low molecular weight mimic of superoxide dismutase. The invention further relates to a method of using the complex comprising treating plant and animal cells with an amount of the complex sufficient to reduce or prevent superoxide radical-induced toxicity.
REFERENCES:
patent: 4172072 (1979-10-01), Ashmead
patent: 4216143 (1980-08-01), Ashmead
patent: 4346174 (1982-08-01), Yasuda
patent: 4530963 (1985-07-01), Devoe et al.
patent: 4758422 (1988-07-01), Quay
Plowman, J. E. et al. (1984) J. Inorg. Biochem. 20(3), 183.
Rabinowitch, H. D., et al. (1987) Free Radical Biology & Medicine 3, 125-131.
Archibald et al; Archives of Biochemistry and Biophysics, vol. 215, No. 2, May, 1982; pp. 589-596.
Archibald et al; Archives of Biochemistry and Biophysics, vol. 214, No. 2, Apr. 1, 1982; pp. 452-463.
Archibald; Copyright 1983 by Elsevier Science Publishing Co., Inc., Gerald Cohen and Robert A. Greenwald, Editors, "Oxy Radicals & Their Scavenger Systems", vol. 1, Molecular Aspects, pp. 207-217.
Chemical Abstracts; vol. 68, No. 15, Apr. 8, 1968-67581n.
Chemical Abstracts: vol. 99, No. 20, Nov. 14, 1983-164612w.
Chemical Abstracts, vol. 96, No. 23, Jun. 7, 1982-195506g.
Chemical Abstracts, vol. 95, No. 9, Aug. 31, 1981-76615m.
Epp et al; 1986 Elsevier Science Publishers B. V. (Biomedical Division) Superoxide and Superoxide Dimutase in Chemistry, Biology and Medicine; G. Rotilio, editor pp. 76-78.
Yamaguchi et al; FEBS 3451, vol. 197, No. 1,2; mar. 1986, pp. 249-252.
Koppenol et al; Archives of Biochemistry and Biophysics, vol. 251, No. 2, Dec., 1986, pp. 594-599.
P. Simon; The Lancet, Aug. 27, 1983; pp. 512-513; Desferrioxamine, Ocular Toxicity and Trace Metals.
Fridovich, "Natural and Synthetic Defenses Against Oxygen Radicals", Environs, Dec. 1986, pp. 2-3.
Darr Douglas J.
Fridovich Irwin
Duke University
Patterson Jr. Charles L.
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