Superoxide dismutase derivatives, method of producing same and m

Details Superoxide dismutase derivatives, method of producing same and m Superoxide dismutase derivatives, method of producing same and m

1987-05-13

1990-11-06

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

435189, 424 943, 424 944, C12N 996, C12N 902, A61K 3748

Patent

active

049686160

ABSTRACT:
Novel superoxide dismutase derivatives are provided in which the enzymatic activity of superoxide dismutase capable of decomposing superoxide, a substance harmful to living organisms, is for the most part maintained with the plasma half-life being significantly prolonged as compared with superoxide dismutase itself. They have pharmacological activities such as anti-inflammatory, anti-ischemic and cerebral edema-preventing activities. Also provided are a method of producing such superoxide dismutase derivatives and medicinal uses of them.

REFERENCES:
patent: 4011169 (1977-03-01), Diehl et al.
patent: 4563349 (1986-01-01), Miyata et al.
patent: 4742004 (1988-05-01), Hartman et al.

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