Superoxide dismutase derivatives

Details Superoxide dismutase derivatives Superoxide dismutase derivatives

1991-12-06

1993-08-24

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

424 943, 424 944, 435188, C12N 902

Patent

active

052388379

ABSTRACT:
Provided are novel superoxide dismutase derivatives represented by the following general formula (I) ##STR1## wherein [SOD] is a superoxide dismutase residue derived by removal of two mercapto groups, and W is a divalent long chain hydrocarbon residue which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of --N(R)-- (R being a lower alkyl group). The SOD derivatives retain most of the enzymatic activities of unmodified SOD and have much longer plasma half-life than unmodified SOD. They are effective for treating various diseases caused by active oxygen species.
Also provided are chemical modifiers to prepare the above SOD derivatives.

REFERENCES:
patent: 4801538 (1989-01-01), Hanada et al.
Pierce 1989 Handbook & Catalogue P.O. Box 117 Rockford, Ill. 61105 pp. 296-297.
M. Inoue et al, Biochemistry, vol. 28, pp. 6619-6624 (1989).
Chemical Abstracts, vol. 115(5), abstract 43323t (1991).
Chemical Abstracts, vol. 112(14), abstract 125189f (1990).

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