Superoxide dismutase combined with a poly(alkylene oxide)

Details Superoxide dismutase combined with a poly(alkylene oxide) Superoxide dismutase combined with a poly(alkylene oxide)

1989-02-02

1991-11-19

Stone, Jacqueline

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435175, 435177, 435188, 435189, 424 943, 424 944, C12N 1108, C12N 902, A61K 3750

Patent

active

050665901

ABSTRACT:
Superoxide dismutase is chemically modified with poly(alkylene oxide), the modified superoxide dismutase having a molecular structure in which both ends of a poly(alkylene oxide) molecule are attached to superoxide dismutase. The modified superoxide dismutase can be used to remove toxic substances derived from oxygen, from the blood circulation in a living body, and has a longer half life in the blood circulation as compared to superoxide dismutase which has not been modified.

REFERENCES:
patent: 3654083 (1972-04-01), Moelker
Boccu, E. et al. (1983), Zeitschrift Fuer NaturForschung 38, 94-99.
F. M. Veronese et al., "Anti-Inflammatory and Pharmacokinetic Properties of Superoxide Dismutase Derivatized with Polyethylene Glycol via Active Esters", Chemical Abstracts, vol. 100, No. 3, Jan. 16, 1984, pp. 28-29.
C. O. Beauchamp et al., "A New Procedure for the Synthesis of Polyethylene Glycol-Protein Adducts; Effects on Function, Receptor Recognition, and Clearance of Superoxide Dismutase, Lactoferrin, and Alpha2-Macroglobulin", Chemical Abstracts, vol. 99, No. 5, Aug. 1, 1983, p. 284.

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