Superoxide dismutase analogs having novel binding properties

Details Superoxide dismutase analogs having novel binding properties Superoxide dismutase analogs having novel binding properties

1990-08-01

1992-12-15

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

4352523, 435254, 4353201, 536 27, 424 944, C12N 902, C12N 121, C12N 114, C12N 1553

Patent

active

051716801

ABSTRACT:
Superoxide dismutase (SOD) analogs whose amino acid sequence includes a heterologous peptide domain such as the RGDX tetrapeptide found in fibronectin or the LGGAKQAGDV decapeptide found in fibrinogen that enables the analog to bind to a moiety that is normally present at sites of desired SOD therapy. The domain is incorporated into the SOD sequence in a manner in which it is available to interact with such moieties but does not destroy the enzymatic activity of the molecule. The inclusion of the domain enables the analog to more readily access the target tissue upon which it is to act and/or increase the corporeal half-life of the molecule.

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