Superoxide dismutase-2 expression for glaucoma diagnosis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S007100, C435S091200, C435S091510, C435S287200, C536S023200, C536S023500

Reexamination Certificate

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07807363

ABSTRACT:
The present invention concerns a method for diagnosing or monitoring elevated intraocular pressure or glaucoma in a patient comprising providing a biological sample from the patient and measuring the expression level of a superoxide dismutase-2 (SOD-2) gene in the biological sample. The present invention also concerns methods for treating glaucoma or elevated intraocular pressure in a patient comprising administering to a patient an effective amount of an agent that modulates SOD-2 expression or SOD-2 activity.

REFERENCES:
patent: 6716581 (2004-04-01), Lenz et al.
patent: 2004/0009959 (2004-01-01), Potter et al.
patent: 2004/0067519 (2004-04-01), Lenz et al.
patent: 2004/0091919 (2004-05-01), Bennett et al.
patent: 2005/0202488 (2005-09-01), Brown et al.
Aoyama et al., Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases, Ann Neurol., 2000, vol. 47(4):524-527.
Chung-Man et al., Differential expression of manganese superoxide dismutase and catalase in lung cancer, Cancer Research, 2001, vol. 61(23): 8578-8585.
De Leo et al., Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease, Neuroscience Letters, 1998, vol. 250(3):173-176.
Friedman et al., SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness, Blood, 2004, vol. 104(8): 2565-2573.
Hiroi et al., Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese, Biochem Biophys Res Commun,1999, vol. 261(2):332-339.
Kasahara et al., SOD2 protects agains oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration, Invest Opthalmol Vis Science, 2005, vol. 46(9):3426-3434.
Li et al., Phenotypic changes induced in human breast cancer cells by overexpresion of manganese-containing superoxide dismutase, Oncogene, 1995, vol. 10:1989-2000.
Liang et al., Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain, Neuroscience Letters, 1997, vol. 225:73-76.
Lushchak et al., Diethyldithiocarbamate inhibits in vivo Cu,Zn-superoxide dismutase and perturbs free radical processes in the yeastSaccharomyces cerevisiaecells, 2005, vol. 338:1739-1744.
Melov et al., Extension of life-span with superoxide dismutase/catalase mimetics, 2000, vol. 289:1567-1569.
O'Hara et al., Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue, Arthritis Research, 2000, vol. 2:142-144.
Qi et al., SOD2 gene transfer protects against optic neuropathy inducted by deficiency of Complex I, Ann Neurol, 2004, vol. 56:182-191.
Salvemini et al., SOD mimetics are coming of age, Nature Reviews, 2002, vol. 1:367-374.
Tanaka et al., Inducible expression of manganese superoxide dismutase by phorbol 12-myristate 13-acetate is mediated by SP1 in endothelial cells, Anterioscler Thromb Vasc. Biol., 2000, vol. 20:392-401.
Urieli-Shoval et al., Widespread expression of serum amyloid A in histologically normal human tissues:predominant localization to the epithelium, 1998, vol. 46(12):1377-1384.
Wang et al., Increased expression of serum amyloid A in human glaucoma and effecti on IOP, ARVO Abstract 2006; Control Tracking No. 06-A-3606-ARVO.

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