Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from a tree having matured height of...
Reexamination Certificate
2008-07-22
2008-07-22
Tate, Christopher R. (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from a tree having matured height of...
C424S774000
Reexamination Certificate
active
11191650
ABSTRACT:
A method for the extraction of pharmacologically active components from the oleander plant using supercritical carbon dioxide and combining the extraction with other isolation methods. The extraction is carried out using carbon dioxide at supercritical conditions, with or without the addition of a modifier. The isolated product is recovered in higher yield than with traditional hot water extraction.
REFERENCES:
patent: 3833472 (1974-09-01), Yamauchi
patent: 4554170 (1985-11-01), Panzner et al.
patent: 5135745 (1992-08-01), Ozel
patent: 5236132 (1993-08-01), Rowley, Jr.
patent: 5598979 (1997-02-01), Rowley, Jr.
patent: 6517015 (2003-02-01), Rowley, Jr.
patent: 6565897 (2003-05-01), Selvaraj et al.
patent: 6715705 (2004-04-01), Rowley, Jr.
patent: 2005/0112059 (2005-05-01), Newman et al.
Raventos et al, Application and Possibilities of Supercritical Co2 Extration in Good Processing Industry: An Overview, Food Science Tech. Int, 2002, vol. 8, pp. 269-284.
Lawrence TS. Ouabain sensitizes tumor cells but not normal cells to radiation. Int J Radiat Oncol Biol Phys. Oct. 1988;15(4):953-8.
Manna SK, Sah NK, Newman RA, Cisneros A, Aggarwal BB. Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase. Cancer Res. Jul. 15, 2000;60(14):3838-47.
McConkey DJ, Lin Y, Nutt LK, Ozel HZ, Newman RA. Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. Cancer Res. Jul. 15, 2000;60(14):3807-12.
Mekhail T, Kellackey C, Hutson T, Olencki T, Budd GT, Peereboom D, Dreicer R, Elson P, Ganapathi R, Bukowski R. Phase I study of Anvirzel in patients with advanced solid tumors. Am. Soc. Clin. Oncol. vol. 20 (2001) 82b.
Newman RA, Cisneros A, Felix E, Vijjeswarapu M, Lin Y, Yang P, Azadi P. Composition and preliminary pharmacology studies with Arnvirzel: An extract ofNerium oleander. J. Herbal Pharmacotherapy. vol. 13 (2001) 1-15.
Pathak S, Multani AS, Narayan S, Kumar V, Newman RA. Anvirzel, an extract ofNerium oleander, induces cell death in human but not murine cancer cells. Anticancer Drugs. Jul. 2000;11(6):455-63.
Raventos M, Durate S, Alarcon R. Application and Possibilities of Supercritical CO2 Extraction in Food Processing Industry: An Overview. Food Sci. Tech. Int. vol. 8 (5) (2002) 269-284.
Verheye-Dua FA, Bohm L. Influence of ouabain on cell inactivation by irradiation. Strahlenther Onkol. Mar. 1996;172(3):156-61.
Verheye-Dua FA, Bohm L. Influence of apoptosis on the enhancement of radiotoxicity by ouabain. Strahlenther Onkol. Apr. 2000;176(4):186-91.
Davis Deborah A.
Innovar L.L.C.
Matos Rick
Phoenix Biotechnology, Inc.
Tate Christopher R.
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