Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1994-03-29
1996-08-13
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530325, 530326, A61K 3816
Patent
active
055457169
ABSTRACT:
The subject invention concerns novel peptide agonists and antagonists of staphylococcal enterotoxin A. Specifically exemplified are peptide agonists which stimulate T cell proliferation.
REFERENCES:
Huang J Biol Chem 262, 7006, 1987.
Betley J. Bacteriol 170, 34-41, 1988.
Johnson, H. M., H. I. Magazine (1988) "Potent Mitogenic Activity of Staphylococcal Enterotoxin A Requires Induction of Interleukin 2" Int. Arch. Allergy Appl. Immunol. 87:87-90.
Carisson, R. etal. (1988) "Binding of Staphylococcal Enterotoxin A to Accessory Cells is a Requirement for its Ability to Activate Human T Cells" The Journal of Immunology 140(8):2484-2488.
Fleischer, B., H. Schrezemeier (1988) "T Cell Stimulation by Staphylococcal Enterotoxins" J. Exp. Med. 167:1697-1707.
Mollick, J. A. et al. (1989) "Class II MHC Molecules Are Specific Receptors for Staphylococcus Enterotoxin A" Science 244:817-820.
Janeway, C. A. Jr. et al. (1989) "T-Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior" Immunological Reviews 107:61-88.
White, J. et al. (1989) "The V.beta.-Specific Superantigen Staphylococcal Enterotoxin B: Stimulation of Mature T Cells and Clonal Deletion in Neonatal Mice" Cell 56:27-35.
Herman, A. et al. (1991) "Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses" Ann. Rev. Immunol. 9:745-772.
Kawabe, Y., A. Ochi (1991) "Programmed cell death and extrathymic reduction of V.beta.8+ CD4+T cells in mice tolerant ot Staphylococcus aureus enterotoxin B" Nature 349:245-248.
Kawabe, Y., A. Ochi (1990) "Selective Anergy of v.beta.8+, CD4+T Cells in Straphylococcus Enterotoxin B-primed Mice" J. Exp. Med. 172:1065-1070.
Rellahan, B. L. et al. (1990) "In vivo Induction of anergy in Peripheral V.beta.8+ T Cells by Straphylococcal Enterotoxin B" The Journal of Experimental Medicine 172:1091-1100.
Fischer, H. et al. (1990) "Production of TNF-.alpha. and TNF-.beta. by Staphylococcal Enterotoxin A Activated Human T Cells" Journal of Immunology 144(12):4663-4669.
Gjorloff, A. et al. (1991) "Induction of Interleukin-1 in Human Monocytes by the Superantigen Staphlococcal Enterotoxin A Requires the Participation of T Cells" Cellular Immunology 137:61-71.
Scholl, P. R. et al. (1992) "Role of Protein Tyrosine Phosphorylation in Monokine Induction by the Staphylococcal Superantigen Toxic Shock Syndrome Toxin-1" The Journal of Immunology 148(7):2237-2241.
Yokota, S. et al. (1988) "Enhancement of Antigen- and Mitogen-Induced Human T Lymphocyte Proliferation by Tumor Necrosis Factor-.alpha." The Journal of Immunology 140(2):531-536.
Griggs, N. D. et al. (1992) "Mapping of Multiple Binding Domains of the Superantigen Staphylococcal Enterotoxin A for HLA" The Journal of Immunology 148(8):2516-2521.
Acha-Orbea, H. et al. (1988) "limited Heterogeneity of T Cell REceptors from Lymphocytes Mediating Autoimmune Encephalomyelitis Allows Specific Immune Intervention" Cell 54:263-273.
Offner, H. et al. (1991) "T Cell REceptor Peptide Therapy Triggers Autoregulation of Experimental Encephalomyelitis" Science 251:430-432.
Kim, C. et al. (1991) "Reduction of Lupus Nephritis in MRL/lpr Mice by a Bacterial Superantigen Treatment" J. Exp. Med. 174:1431-1437.
Grossman, D. et al. (1990) "Dissociation of the Stimulatory Activities of Staphylococcal Enterotoxins for T Cells and Monocytes" J. Exp. Med. 172:1831-1841.
Grossman, D. et al. (1991) "Mutation of the Disulfide Loop in Staphylococcal Enterotoxin A" The Journal of Immunology 147(10):3274-3261.
Pontzer, C. H. et al (1989) "Localization of an Immune Functional Site on Staphylococcal Enterotoxin A Using the Synthetic Peptide Approach" The Journal of Immunology 143(1):280-284.
Pontzer, C. H. et al. (1990) "Site of Nonrestrictive Binding of SEA to Class II MHC Antigens" Int. Arch. Allegy Appl. Immunol. 93:107-112.
Griggs Nathan D.
Johnson Howard M.
Pontzer Carol H.
Lukton David
University of Florida
Warden Jill
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