Superactive human insulin analogues

Details Superactive human insulin analogues Superactive human insulin analogues

1988-11-18

1991-02-12

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530303, 514866, C07K 740, A61K 3702

Patent

active

049924176

ABSTRACT:
Superactive insulin analogues are provided. These insulin analogues are used in therapeutically effective amounts in the preparation of pharmaceutical compositions for administration to diabetic patients.

REFERENCES:
patent: 3420810 (1969-01-01), Katsoyannis et al.
patent: 3883496 (1975-05-01), Geiger
patent: 3883500 (1975-05-01), Geiger
patent: 4421685 (1983-12-01), Chance et al.
patent: 4430266 (1984-02-01), Frank
patent: 4459228 (1984-07-01), Grime et al.
patent: 4569791 (1986-02-01), Frank et al.
patent: 4569792 (1986-02-01), Frank et al.
patent: 4581165 (1986-08-01), Frank et al.
patent: 4652547 (1987-03-01), Chance et al
patent: 4652548 (1987-03-01), Chance et al.
Fischer, Biol. Chem. Hoppe-Seyler, 366, 521-525, May 1985.
Chemical Abstracts, vol. 101, 1984, p. 72, abstract No. 84120d.
Schwartz et al., "A Superactive Insulin: [B 10-Aspartic acid]Insulin (Human)", Proc. Nat'l Acad. Sci., U.S.A., vol. 84, pp. 6408-6411, Sep. 1987.
Chemical Abstracts, vol. 105, 1986, p. 87 abstract No. 184142p.
Chemical Abstracts, vol. 97, 1982, p. 909, abstract No. 216734t.
Botstein, D. and Shortle, D., Strategies and Applications of in Vitro Mutagenesis, Science, vol. 229, pp. 1193-1201, 1985.
Brange et al., "Monomeric Insulins Obtained by Protein Engineering and Their Medical Implications", Nature, 33:679 (Jun. 16, 1988).
Chance, R. E., Hoffman, J. A., Kroeff, F. P., Johnson, M. G., Schirmer, E. W., and Bromer, W. W., The Lilly Research Labs., Ind.
Katsoyannis, P. G., Tometsko, A. and Zalut, C., Insulin Peptides, XII, Human Insulin Generation by Combination of Synthetic A & B. Chains, Journal of the American Chemical Society, 88, 166, 1966.
Schwartz C. P., Burke, C. T. and Katsoyannis, P. G., [12-Asparagine-B] Human Insulin--An Analogue With Modification in the Hydrophobic Core of Insulin, Int. J. Peptide Protein Res. 17, pp. 243-255, 1981.
Katsoyannis, P. G. and Tometsko, A., Insulin Synthesis By Recombination of A and B Chains: A Highly Efficient Method, Proceedings of the Natl. Acad. of Sciences, vol. 55, No. 6, pp. 1554-1561, 1966.
Schwartz, G. P. and Katsoyannis, P. G., Insulin Peptides, Part XXIII. The Syntheses of a Hexadecapeptide Derivative Related to the B Chain of Human Insulin, Journal of the Chemical Society, Perkins Transactions I, 1973.
Schwartz, G. P. and Katsoyannis, P. G., Insulin Peptides. Part XXIV. A Novel Synthesis of the Human Insulin B Chain S-Sulphonate, Journal of the Chemical Society, Perkin Transactions I, 1973.
Chan, S. J., Seino, S., Gruppuso, P. A., Schwartz, R., Steiner, D. F., A Mutation in the B Chain Coding Region is Associated With Impaired Proinsulin Conversion in a Family With Hyperproinsulinemia, Proc. Natl. Acad. Sci. U.S.A., vol. 84, pp. 2194-2197, 1987.
Katsoyannis, P. G., Tometsko, A, Zalut, C., Johnson, S. and Trakatellis, A. C., Studies on the Synthesis of Insulin From Natural and Synthetic A and B Chains. I. Splitting of Insulin and Isolation of the S-Sulfonated Derivatives of the A and B Chains, Biochemistry, v, pp. 2635-2642, 1967.
Katsoyannis, P. G., Trakatellis, A. C., Johnson, S., Zalut, C. and Schwartz, G., Studies on the Synthesis of Insulin from Natural and Synthetic A and B Chains, II. Isolation of Insulin from Recombination Mixtures of Natural A and B Chains, Biochemistry, 6, pp. 2642-2655, 1967.
Katsoyannis, P. G., Trakatellis, A. C., Zalut, C., Johnson, S. Tometski, A., Schwartz, G., and Ginos, J., Studies on the Synthesis of Insulin from Natural and Synthetic A and B Chains. III. Synthetic Insulins, Biochemistry, pp. 2656-2668, 1967.
Schwartz, G. and Katsoyannis, P. G., Synthesis of Human [9-Leucine-B]Insulin, Biochemistry, 15, pp. 4071-4076, 1976.
Schwartz et al., J. Chem. Research (M), The Synthesis of [10-Leucine-B ] Human Insulin, A Biologically Active Analogue, pp. 2453-2466, 1977.
Schwartz, G. P. and Katsoyannis, P. G., The Synthesis of [10-Leuicine-B] Human Insulin, a Biologically Active Analogue, Journal of Chem. Res. (S), pp. 220-221, 1977.
Katsoyannis, P. G., Structure and Function Relationships In Insulin: A Synthetic Approach, Elsvier North Holland, Inc., pp. 171-192, 1980.
Katsoyannis, P. G., New Synthetic Insulins, Treatment of Early Diabetes, pp. 319-328, 1979.
Burke, G. T., Schwartz, G. and Katsoyannis, P. G., Nature of the B.sup.10 Amino Acid Residue, Int. J. Peptide Protein Res., 23, pp. 384-401, 1984.
Schwartz, G., Burke, G. T., and Katsoyannis, P. G., The Importance Of the B.sup.10 Amino Acid Residue to the Biological Activity Of Insulin. [Lys.sup.10 -B] Human Insulin, Journal of Protein Chemistry, vol. 1, No. 3, pp. 177-189, 1982.
Ferderigos, N., Cosmatos, A., Ferderigos, A. and Katsoyannis, P. G. [21-Arginine-A] Insulin-A Biologically Active Analog, Int. J. Peptide Protein Res. 13, pp. 43-53, 1979.
Cosmatos, A., Ferderigos, N., and Katsoyannis, P. G., Chemical Synthesis of [Des(Tetrapeptide B.sup.27-30), TYR(NH.sub.2).sup.26 -B] and [DES (Pentapeptide B.sup.26-30), PHE(NH.sub.2).sup.25 -B] Bovine Insulins, Int. J. Peptide Protein Res. 14, pp. 457-471, 1979.
Schwartz, G. and Katsoyannis, P. G., Synthesis of Des(tetrapeptide B.sup.1-4) and Des(pentapeptide B.sup.1-5) Human Insulins. Two Biologically Active Analogues, Biochemistry, 17, pp. 4550-4556, 1978.
The Effect of Modifications of the A.sup.5 and A.sup.19 Amino Acid Residues on the Biological Acitivity of Insulin. [Leu.sup.5 -A] and [Phe.sup.19 -A] Sheep Insulins, Journal of Protein Chemistry, vol. 2, pp. 147-170, 1983.
Schwartz, G., Burke, G. T., Chanley, J. D., and Katsoyannis, P. G., An Insulin Analogue Possessing Higher in Vitro Biological Activity Than Receptor Binding Affinity. [21-Proline-B]Insulin, Biochemstry] vol. 22, pp. 4561-4567, 1983.
Kitagawa, K., Ogawa, H., Burke, G. T., Chanley, J. D., and Katsoyannis, P. G., Critical Role of the A.sup.2 Amino Acid Residue in the Biological Activity of Insulin: [2-Glycin-A]-and [2-Alanine-A]Insulins, Biochemistry, vol. 23, pp. 1405-1413, 1984.
Kitagawa, K., Ogawa, H., Burke, G. T., Chanley, J. D., and Katsoyannis, P. G., Interaction between the A.sup.2 and A.sup.19 Amino Acid Residues Is of Critical Importance for High Biological Activity in Insulin: [19-Leucine-A]Insulin, Biochemistry, vol. 23, pp. 4444-4448, 1984.

Affiliated with

Also associated with

Rating

Superactive human insulin analogues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Superactive human insulin analogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Superactive human insulin analogues will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-20600