.sup.99m Tc.sup.(III) myocardial imaging agents which are non-re

Details .sup.99m Tc.sup.(III) myocardial imaging agents which are non-re .sup.99m Tc.sup.(III) myocardial imaging agents which are non-re

1988-03-11

1989-01-03

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 534 14, A61K 4902, C07F 1300

Patent

active

047956267

ABSTRACT:
A cationic .sup.99m Tc.sup.III myocardial imaging agent is disclosed which has a relatively negative redox potential. This prevents in vivo reduction of the Tc(III) to Tc(II). The redox potential of the Tc(III) is controlled by complexing the Tc with both hard and soft atoms. Preferably four of the atoms complexed to the Tc(III) are hard atoms such as nitrogen or oxygen and the remaining two are soft atoms such as phosphorous or arsenic. These imaging agents are particularly useful in imaging the human heart.

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